Results 41 to 50 of about 6,997,542 (254)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Spatial and temporal variation of extremely abundant maxima of precipitation in Hungary during the period between 1951 and 2010

International Journal of Horticultural Science, 2012
The study deals with the accumulated database of 16 meteorological stations in Hungary during a period of 60 years. The purpose was to reveal the spatial and temporal structure of the appearance of extreme values in the daily distribution of data ...
L. Lakatos, Z. Sümeghy, M. Soltész, J. Nyéki   +3 more
doaj   +1 more source

Biases in Estimating Long‐Term Recurrence Intervals of Extreme Events Due To Regionalized Sampling

Geophysical Research Letters, 2023
Preparing for environmental risks requires estimating the frequencies of extreme events, often from data records that are too short to confirm them directly. This requires fitting a statistical distribution to the data.
Moutassem El Rafei, Steven Sherwood, Jason Evans, Andrew Dowdy, Fei Ji   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Cramer-von Mises and Anderson-Darling goodness of fit tests for extreme value distributions with unknown parameters [PDF]

, 2004
The use of goodness of fit tests based on Cramer-von Mises and Anderson-Darling statistics is discussed, with reference to the composite hypothesis that a sample of observations comes from a distribution, FH, whose parameters are unspecified.
Laio, Francesco, Francesco Laio
core   +1 more source

Characteristics of Extreme Runoff in Beijiang River Basin during Dry Season from 1954 to 2020

Renmin Zhujiang
This paper utilized the daily average flow data from 1954 to 2020 at the Shijiao control station within the Beijiang River Basin. It also employed indicators of hydrological alteration (IHA), heuristic segmentation algorithms, Mann-Kendall trend test ...
ZENG Zhiping, ZHENG Yanhui, ZHOU Yueying, GU Xihui, HE Yanhu   +4 more
doaj   +2 more sources

Étude de l'impact de l'extension et de la densification du tissu urbain sur les coefficients de ruissellement dans le bassin versant des oueds El-Ghrich et El-Greb (Tunis) par l'application de la méthode SCS aux évènements de septembre 2003

Physio-Géo, 2016
September 2003 was exceptionally rainy in all Grand Tunis. During that month, the rainfall exceeded 345 mm. This represents 11 times its average observed in the station of Tunis-Carthage.
Noômène Fehri, Yadh Zahar
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source