Results 51 to 60 of about 6,997,542 (254)
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
, 2019 Sea surface wind, especially extreme winds, plays a crucial role in coastal safety including flooding and coastal erosion mainly by changing sea level and ocean wind waves, and the regional characteristics of sea surface wind can be in uenced by global ...
최원근, 장찬주, 김철호
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Modelarea dinamicii temporale a doborâturilor produse de vânt, prin metoda evenimentelor extreme [Modeling of temporal dynamics of windthrow by extreme events method] [PDF]
Bucovina Forestieră, 1999 This paper presents a likehood model for estimating the risk of windthrow by extreme value analysis. We use the Gumbel model for modelling the catastrophic windthrow at the European level through that we can estimate the probability to appear wind ...
Popa I
doaj
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Extreme Value Analysis of Teletraffic Data [PDF]
An empirically verified characteristic of the expanding area of Internet is the longtailness of phenomena such as cpu time to complete a job, call holding times, files lengths requested, inter-arrival times and so on.
Panaretos, John, Tsourti, Zoi
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MathematicsThis paper proposes a computationally efficient framework for estimating first-passage probabilities of nonlinear structures under stochastic seismic excitations. The methodology integrates Optimal Latinized Partially Stratified Sampling (OLPSS) with the
Bao-Hua Liu, Yan Cao, Long-Wen Zhang
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Extreme Value GARCH modelling with Bayesian Inference [PDF]
Extreme value theory is widely used financial applications such as risk analysis, forecasting and pricing models. One of the major difficulties in the applications to finance and economics is that the assumption of independence of time series ...
Les Oxley +3 more
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