Results 51 to 60 of about 662,489 (267)
Extreme values in ionospheric radio propagation
Annals of Geophysics, 2002 Proposals are made for Earth-space and space-space paths to apply the term ?propagation degradation probability?, analogous to ?basic circuit reliability?
P. A. Bradley
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Estimation of the value-at-risk parameter: Econometric analysis and the extreme value theory approach [PDF]
Ekonomski Anali, 2006 In this paper different aspects of value-at-risk estimation are considered. Daily returns of CISCO, INTEL and NASDAQ stock indices are analyzed for period: September 1996 - September 2006. Methods that incorporate time varying variability and heavy tails
Mladenović Zorica, Mladenović Pavle
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Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
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GeoHazardsEstimation of so-called return levels for environmental extremes is of importance for risk assessment. A particular challenge is to find estimates corresponding to long return periods, as uncertainties in the form of confidence intervals became too wide ...
Jesper Rydén
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Temporal Variability of Temperature Extremes in the Sardinia Region (Italy)
Hydrology, 2020 In this paper, the temporal tendencies of temperature data from the island of Sardinia (Italy) were analyzed by considering 48 data series in the period 1982–2011.
Tommaso Caloiero, Ilaria Guagliardi
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Compound Inverse Rayleigh as an Extreme Wind Speed Distribution and Its Bayes Estimation
Energies, 2022 This paper proposes the Compound Inverse Rayleigh distribution as a proper model for the characterization of the probability distribution of extreme values of wind-speed.
Elio Chiodo +2 more
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Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
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Quantifying Extreme Values in Geomagnetic Perturbations Using Ground Magnetic Records
Space WeatherWe comprehensively analyzed geomagnetic perturbations using ground magnetic records from over 400 stations spanning four solar cycles, from 1976 to 2023. We assess the perturbations in the three magnetic components separately.
J. Rodríguez‐Zuluaga +4 more
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