Results 51 to 60 of about 12,157,399 (307)

Academic attainment and special educational needs in extremely preterm children at 11 years of age : the EPICure Study [PDF]

, 2009
Aim: To assess academic attainment and special educational needs (SEN) in extremely preterm (EP) children in middle childhood. Methods: Of 307 EP (=25 weeks) survivors born in the UK and Ireland in 1995, 219 (71%) were re-assessed at 11 years, with a
Hennessy, Enid M., Wolke, Dieter, Johnson, Samantha J., Smith, R. (Rebecca), Trikic, Rebecca, Marlow, Neil   +5 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Behavioural symptoms of attention deficit/hyperactivity disorder in preterm and term children born small and appropriate for gestational age : a longitudinal study [PDF]

, 2010
Background It remains unclear whether it is more detrimental to be born too early or too small in relation to symptoms of attention deficit/hyperactivity disorder (ADHD).
Kajantie E, Dieter Wolke, Aulikki Lano, Kati Heinonen, Andersson Sture, Lano Aulikki, Eriksson Johan G, Andersson, Sture, Lano A, Kajantie, Eero, Raikkonen, Katri, Johan G Eriksson, Eero Kajantie, Heinonen, Kati, Räikkönen K, Eriksson, Johan G., Pesonen AK, Räikkönen Katri, Sture Andersson, Andersson S, Heinonen Kati, Heinonen K, Eriksson, Johan, Wolke Dieter, Eriksson JG, Wolke, Dieter, Lano, Aulikki, Katri Räikkönen, Kajantie Eero, Pesonen Anu-Katriina, Anu-Katriina Pesonen, Pesonen, Anu-Katriina, Wolke D   +32 more
core   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A Preterm Infant With Gestational Age of 21+4 Weeks

Clinical Case Reports
We report a case of a male infant who was conceived through in vitro fertilization, with a gestational age of 21+4 weeks. The infant was discharged home at 42 weeks' postmenstrual age without significant cranial morbidities.
Haifeng Zong, Bingchun Lin, Yingsui Huang, Shan Jiang, Yurong Yuan, Xiaoyuan Xiong, Zhichun Feng, Chuanzhong Yang   +7 more
doaj   +1 more source

Oxygen Targeting in Extremely Low Birth Weight Infants [PDF]

Pediatrics, 2016
This Clinical Report was reaffirmed September 2023. The use of supplemental oxygen plays a vital role in the care of the critically ill preterm infant, but the unrestricted use of oxygen can lead to unintended harms, such as chronic lung disease and retinopathy of prematurity.
James J. Cummings, Richard A. Polin, Kristi L. Watterberg, Brenda Poindexter, James J. Cummings, William E. Benitz, Eric C. Eichenwald, Brenda B. Poindexter, Dan L. Stewart, Susan W. Aucott, Jay P. Goldsmith, Karen M. Puopolo, Kasper S. Wang   +12 more
openaire   +2 more sources

Association of in utero magnesium exposure and spontaneous intestinal perforations in extremely low birth weight infants [PDF]

, 2017
Determine whether antenatal exposure to magnesium is associated with spontaneous intestinal perforation in extremely low birth weight infants (≤1000 g)
Cotten,, Hornik,, Downey,, Laughon,, Tolia,, Smith,, Clark,   +6 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source