Results 41 to 50 of about 39,435 (216)

The mechanism of labor in nonhuman primates: A look inside

The Anatomical Record, EarlyView.
Abstract While in humans, the flexed position of the fetus and its rotating course down the birth canal are well documented, in other primates the mechanism of labor is unknown. Despite the lack of comparative data, it is commonly assumed that the human obstetric mechanism is unique, and anthropologists have disputed when and why the transition to the ...
Melissa K. Stoller
wiley   +1 more source

A biomimetic ducted nipple reveals gestational age‐dependent deficits in suction generation in a neonatal pig model

The Anatomical Record, EarlyView.
Abstract All infant mammals must suckle in order to effectively acquire milk from a nipple. Yet, not all infants are able to do so. Preterm infants in particular face significant feeding challenges, often failing to establish successful breastfeeding due to complex neurophysiologic challenges.
Max Sarmet, Emily C. Volpe, Elska B. Kaczmarek, Maressa E. Kennedy, Ani E. Smith, Hannah E. Shideler, Harlow I. Smith, Dylan J. Anderson, Thomas H. Stroud, Christopher J. Mayerl   +9 more
wiley   +1 more source

From early prevention to invasive treatment: dental care utilization and outcomes according to gestational age in preterm children

BMC Oral Health
Background Preterm birth is associated with long-term developmental vulnerability, including altered dental development and oral health. Although preterm children tend to visit dental clinics earlier and receive preventive care more frequently than full ...
Han Gill Lee, Seong Joon Lee, Ko Eun Lee, Je Seon Song, Hyung-Jun Choi, Jaeho Lee, Chung-Min Kang   +6 more
doaj   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Extremely Preterm Infants Have a Higher Fat Mass Percentage in Comparison to Very Preterm Infants at Term-Equivalent Age

Frontiers in Pediatrics, 2020
Background: Early nutritional support of preterm infants is important because it influences long-term health and development. Body composition has an influence on cardiovascular disease, metabolic syndrome, and neurocognitive outcome in the long term ...
Marlies Bruckner, Zahra Khan, Christoph Binder, Nicholas Morris, Bernadette Windisch, Sandra Holasek, Berndt Urlesberger   +6 more
doaj   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Implementation of developmental care in routine NICU practice and early clinical outcomes in preterm infants

Frontiers in Pediatrics
IntroductionDespite improved survival of preterm infants, neonatal complications and long-term morbidity remain high, highlighting the need for optimized care in neonatal intensive care units. Developmental care aims to reduce stress and better align the
Halyna Pavlyshyn, Iryna Sarapuk
doaj   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Analysis of clinical investigation (device) initial submissions received by the Medicines and Healthcare products Regulatory Agency between January 2022 and December 2025

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse clinical investigation‐device initial submissions received by the MHRA between January 2022 and December 2025. Methods Data on submissions were extracted from the clinical investigations unit data bank; software as medical devices were not included. The predefined primary end‐point was submission type.
Andrea Manfrin, Mark Grumbridge, Daniel Hill, Crina Cacou, Graham Warren, James Pound, Jacob George, Alejandro F. Frangi   +7 more
wiley   +1 more source

Multiple brain abscesses in an extremely preterm infant and a 12-year follow up: a case report

Italian Journal of Pediatrics, 2022
Background Brain abscesses are uncommon but life-threatening in extremely preterm (EP, Gestational Age 
Shulin Pan, Su Lin, Jing Lin, Shangqin Chen, Zhenlang Lin   +4 more
doaj   +1 more source