Results 71 to 80 of about 1,168,154 (292)

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Factors associated with preterm delivery in women admitted to hospitals in Khorramabad: A case control study [PDF]

Background: Preterm birth is the leading cause of neonatal mortality and a major public health concern. This study aimed to determine factors influencing preterm labor in women referring to hospitals in Khorramabad in 2009-10. Materials and Methods: This
بیرجندی, مهدی, کامران, عزیز, لرزاده, ناهید, ابراهیم زاده, فرزاد, بختیار, کتایون, پورنیا, یداله   +5 more
core   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Trichosporon asahii Infection in an Extremely Preterm Infant in China

Infection and Drug Resistance, 2022
Na Wang1 *, Jing-yi Tang2 *, Zi Wang,3 Liu-yao Wang,4 Tian-tian Song,5 Bei-bei Li,5 Lin Wang5 1Department of Pediatrics, Wuhan No. 1 Hospital, Wuhan, People’s Republic of China; 2Department of Pharmacy, Wuhan No.
Wang N, Tang JY, Wang Z, Wang LY, Song TT, Li BB, Wang L   +6 more
doaj  

Analysis of clinical investigation (device) initial submissions received by the Medicines and Healthcare products Regulatory Agency between January 2022 and December 2025

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to analyse clinical investigation‐device initial submissions received by the MHRA between January 2022 and December 2025. Methods Data on submissions were extracted from the clinical investigations unit data bank; software as medical devices were not included. The predefined primary end‐point was submission type.
Andrea Manfrin, Mark Grumbridge, Daniel Hill, Crina Cacou, Graham Warren, James Pound, Jacob George, Alejandro F. Frangi   +7 more
wiley   +1 more source

Poor attention rather than hyperactivity/impulsivity predicts academic achievement in very preterm and full-term adolescents [PDF]

, 2013
Background: Very preterm (VP) children are at particular risk for attention deficit/hyperactivity disorder (ADHD) of the inattentive subtype. It is unknown whether the neurodevelopmental pathways to academic underachievement are the same as in the ...
Jaekel, Julia, Wolke, Dieter, Bartmann, P.   +2 more
core   +1 more source

Blood Pressure in 6‐Year‐Old Children Born Extremely Preterm

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundAdvances in perinatal medicine have increased infant survival after very preterm birth. Although this progress is welcome, there is increasing concern that preterm birth is an emerging risk factor for hypertension at young age, with ...
Anna‐Karin Edstedt Bonamy, Lilly‐Ann Mohlkert, Jenny Hallberg, Petru Liuba, Vineta Fellman, Magnus Domellöf, Mikael Norman   +6 more
doaj   +1 more source

The Impact of Glycation on Protein Digestibility

ChemFoodChem, EarlyView.
Schematic overview of how protein glycation affects digestibility and downstream nutritional consequences. Glycation‐derived structural modifications reduce protease accessibility, leading to limited hydrolysis and altered peptide generation. These changes decrease amino acid bioavailability and may subsequently contribute to microbiome alterations ...
Lea Hönemann, Simone Lipinski, Jana Raupbach   +2 more
wiley   +1 more source

Longitudinal measurement of the developing grey matter in preterm subjects using multi-modal MRI. [PDF]

, 2015
Preterm birth is a major public health concern, with the severity and occurrence of adverse outcome increasing with earlier delivery. Being born preterm disrupts a time of rapid brain development: in addition to volumetric growth, the cortex folds ...
Eaton-Rosen, Z, Alan Bainbridge, Marlow, N, Nicola J. Robertson, Neil Marlow, M. Jorge Cardoso, Eliza Orasanu, Modat, M, Zach Eaton-Rosen, Robertson, NJ, Melbourne, A, Giles S. Kendall, Sebastien Ourselin, Cardoso, MJ, Ourselin, S, Kendall, GS, Orasanu, E, Bainbridge, A, Andrew Melbourne, Marc Modat   +19 more
core   +1 more source

Fibrin glue pleurodesis for pneumothorax in extremely preterm infants: a case report and literature review

Italian Journal of Pediatrics, 2018
Background Chest tube drainage and mechanical ventilation are effective treatment of symptomatic pneumothorax (PTX), but the best management of persistent (> 7 days) PTX is unknown.
Livia Drovandi, Ilaria Cianchi, Simone Pratesi, Carlo Dani   +3 more
doaj   +1 more source