Results 71 to 80 of about 254,400 (269)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Dual-targeted hybrid nanovesicles coordinated bone-muscle regeneration via regulating the DUSP4/p38 MAPK pathway to reverse osteosarcopenia

Journal of Nanobiotechnology
Osteosarcopenia (OSP), a degenerative syndrome characterized by concurrent osteoporosis and sarcopenia, exhibits persistently high global prevalence due to aging and disuse, yet lacks targeted therapies.
Benchi Che, Yongzhi Cui, Zhengsheng Chen, Yanchun Gao, Lei Luo, Kaiwen zheng, Jiashuo Liu, Yu Xiang, Jiaqi Cheng, Yuanyuan Guo, Qing Li, Dehao Fu   +11 more
doaj   +1 more source

The relation between pelvic varicose veins and lower extremity venous insufficiency in women with chronic pelvic pain

Journal of the Belgian Society of Radiology, 2012
Purpose: To determine the relation between pelvic varicose veins and lower extremity venous insufficiency in women with chronic pelvic pain. Methods and Materials: This study was done in Yuzuncu Yil University Faculty of Medicine, Department of Radiology,
A Bora, S Avcu, H Arslan, E Adali, MD Bulut   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Auto-planning in preoperative shoulder arthroplasty software reduces implant planning time and number of actions

Digital Health
Background Software-based preoperative 3D shoulder arthroplasty implant planning is traditionally done manually and can be time-consuming. Systems like Blueprint © are now using software features that suggest implant positioning and sizing. This study is
Pierre Mahe, Sarah Shank, Arthur de Gast, Maud Reynier   +3 more
doaj   +1 more source

An Echocardiography Training Program for Improving the Left Ventricular Function Interpretation in Emergency Department; a Brief Report

Archives of Academic Emergency Medicine, 2017
Introduction: Focused training in transthoracic echocardiography enables emergency physicians (EPs) to accurately estimate the left ventricular function.
Mary S. Jacob, Hamid Shokoohi, Fabith Moideen, Amelia Pousson, Keith Boniface   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

POSSIBILITIES OF MODERN TECHNIQUES OF PLASTIC AND RECONSTRUCTIVE SURGERY IN THE TREATMENT OF PATIENTS WITH MAJOR POSTTRAUMATIC DEFECTS OF EXTREMITIES (REVIEW)

Travmatologiâ i Ortopediâ Rossii, 2011
Relying on studies of scientific publications we have analyzed possibilities and effectiveness of using various modern techniques of replacement of major posttraumatic defects of tissues of extremities and we have worked out the main lines of improving ...
R. M. Tikhilov, A. Yu. Kochish, L. A. Rodomanova, D. I. Kutyanov, A. O. Afanas’ev   +4 more
doaj   +1 more source