Results 171 to 180 of about 2,322,609 (300)

Effects of Traditional Chinese Medicine for Prevention and Management of Dry Eye Disease: A Systematic Review, Network Meta-Analysis and Meta-Regression of Randomized Controlled Trials. [PDF]

Vision (Basel)
Hu W, Jiang Y, Wong MS, Zhou L.
europepmc   +1 more source

CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome

Advanced Science, EarlyView.
By modeling Lowe syndrome using patient‐derived iPSCs, this study establishes a human disease model that faithfully recapitulates OCRL deficiency‐associated ciliary and cytoskeletal defects. The model enables evaluation of both mutation‐agnostic DNA augmentation and CRISPR‐mediated mutation correction strategies, both of which restore OCRL function and
Siyu Chen, Zhiquan Liu, Wenmin Wang, Qing Wang, Tia J. Kowal, Fan Zhang, Grzegorz Walkiewicz, Faruk Hossen, Herbert M. Lachman, Jinqiong Zhou, Yiting Wang, Yang Sun   +11 more
wiley   +1 more source

Share කරන්න​! ජීවිතයක් බේරා ගන්න​!

This entry includes only an infographic (in Sinhala) and no writeups.On 9th February, the Ethics Eye team published an infographic featuring suicide helplines, urging viewers to share and disseminate the information in order to potentially save ...
Ethics Eye
core   +1 more source

Intraosseous sarcoidosis mimicking orbital apex meningioma: Report of a case. [PDF]

Am J Ophthalmol Case Rep
Chou B, Hattab E, Abecassis J, Clark J.
europepmc   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Periocular morphology during long-term topical ophthalmic treatment: associations with prostaglandin analogs, preservatives, and eyelid manipulation. [PDF]

BMC Ophthalmol
Karaca S, Yilmaz OF, Sahin ZB, Kaya SP, Kirik F, Hepokur M, Oguz H.   +6 more
europepmc   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Selecting Vehicle Comparators in Dry Eye Disease Clinical Trials: Implications for Efficacy and Safety Assessment and Regulatory Outcomes. [PDF]

Ophthalmol Ther
Tunon-Robinson I, Zheng S, Zhao C, Nguyen AK, Gomez-Freeman L.   +4 more
europepmc   +1 more source

Transposable Element Dynamics Drive the Genomic Evolution and Phenotypic Diversification of Allotetraploid Common Carp

Advanced Science, EarlyView.
By integrating 516 whole‐genome resequencing datasets and 236 transcriptomes of allotetraploid common carp, this study establishes the first population‐scale atlas of transposable element (TE) variation in teleost species. TE bursts, relaxed purifying selection, and lineage‐specific loss of ancient insertions shape genome evolution and phenotypic ...
Shuimu Hu, Zhou Jiang, Lin Chen, Gowena Ling Yi Goh, Weijing Li, Qian He, Xintong Chen, Rui Li, Yuxuan Liu, Ning Li, Tao Zhou, Peng Xu   +11 more
wiley   +1 more source

The Impact of a Smartphone Reminder Application on Artificial Tear Adherence in Dry Eye Disease. [PDF]

J Clin Med
Ayaz M, De Barros G, Ahmed K, Travé Huarte S, Kingsnorth A, Wolffsohn JS.   +5 more
europepmc   +1 more source