Results 41 to 50 of about 563,019 (246)

P38 Mitogen-Activated Protein Kinase Protects Against Retinoblastoma Through Regulating USP22/SIRT1/SOST Axis

Frontiers in Oncology, 2022
Retinoblastoma (RB) is the most common intraocular malignancy in children. It has been previously reported that p38 MAPK is related to the pathogenesis of RB. Here we aim at investigating how p38 MAPK affected RB progression through mediating USP22/SIRT1/
Xiaoming Huang, Xiaoming Huang, Jianfeng Wan, Fei Liu, Yang Liu, Lina Wang, Sidi Zhao, Tong Wu, Tong Wu, Fengyuan Sun, Fengyuan Sun   +10 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Orbitofrontal cholesterol granuloma masquerading as frontal sinus mucoceles: report of two cases

BMC Ophthalmology, 2023
Background Two cases of orbitofrontal cholesterol granuloma masquerading as frontal sinus mucoceles were reported to understand image findings, clinical and histopathologic features of orbitofrontal cholesterol granuloma to improve its diagnosis and ...
Ruimiao Li, Mingyu Ren, Wenjing Wang, Ruixin Li, Lili Zhang, Limin Liu   +5 more
doaj   +1 more source

A Generic Pixel Pitch Calibration Method for Fundus Camera via Automated ROI Extraction

Sensors, 2022
Pixel pitch calibration is an essential step to make the fundus structures in the fundus image quantitatively measurable, which is important for the diagnosis and treatment of many diseases, e.g., diabetes, arteriosclerosis, hereditary optic atrophy, etc.
Tengfei Long, Yi Xu, Haidong Zou, Lina Lu, Tianyi Yuan, Zhou Dong, Jiqun Dong, Xin Ke, Saiguang Ling, Yingyan Ma   +9 more
doaj   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Lactoferrin concentration in tears of patients with chronic conjunctivitis and effect of Lacto eyedrops in the multicomponent treatment for this disorder

Journal of Ophthalmology, 2023
Background: Lactoferrin (LF) is a non-heme iron-binding glycoprotein of the transferrin family. It is a natural component of the tear film, has bacteriostatic, bactericidal, fungicidal, antiviral, and antioxidant properties, and thus plays an important ...
Galyna Drozhzhyna, L.Yu. Riazanova, Nataliya Khramenko, L.M. Velychko   +3 more
doaj   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Smartwatch-monitored physical activity and myopia in children: a 2-year prospective cohort study

BMC Medicine
Background While outdoor time's protective role against myopia is established, the relationship between physical activity (PA) and myopia development remains unclear. This study aimed to determine the impact of PA on myopia in children.
Daixi Chen, Jingjing Wang, Jun Chen, Meng Lu, Yuchen Du, Ziyan Zhu, Padmaja Sankaridurg, Zhuoting Zhu, Bo Zhang, Linlin Du, Jinliuxing Yang, Xiangui He, Xun Xu   +12 more
doaj   +1 more source

The associations of lens power with age, axial length and type 2 diabetes mellitus in Chinese adults aged 50 and above

Eye and Vision, 2020
Background To investigate the associations of lens power with age, axial length (AL), and Type 2 diabetes mellitus (DM) in Chinese adults aged 50 and above.
Luyao Ye, Jiangnan He, Xinji Zhang, Yi Xu, Qiuying Chen, Yao Yin, Ying Fan, Lina Lu, Jianfeng Zhu, Haidong Zou, Xun Xu   +10 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source