Results 41 to 50 of about 1,362,172 (290)

A Comprehensive Review on Dry Eye Disease: Diagnosis, Medical Management, Recent Developments, and Future Challenges [PDF]

, 2015
Dry eye syndrome (DES) or keratoconjunctivitis sicca (KCS) is a common disorder of the tear film caused by decreased tear production or increased evaporation and manifests with a wide variety of signs and symptoms.
Askarkar, S, Momin, M, Nighojkar, P, Phadatare, S, Singh, Kamalinder   +4 more
core   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Efficacy of using antibacterial fusidic acid drops in patients with red eye

Journal of Ophthalmology, 2016
Introduction. A red eye includes various etiology diseases of the ocular surface (eyelids, conjunctiva, and cornea) as well as of the vascular tract and lacrimal apparatus, the main feature of which is hyperemia of the conjunctiva of the eye.
G.I.Drozhzhyna, E.V. Sereda, T.B. Gaydamaka, A.L. Molodaia   +3 more
doaj   +1 more source

Accommodative responses under various viewing conditions in surgical patients with intermittent exotropia: an institutional, retrospective study

BMC Ophthalmology, 2022
Purpose To investigate the difference of spherical equivalent (SE) and pupil diameter in adult patients with intermittent exotropia (IXT) under various viewing conditions before and after surgery.
Ziyi Qi, Linlin Du, Jun Chen, Xun Xu, Xiangui He, Jun Qiang   +5 more
doaj   +1 more source

Rates of referable eye disease in the Scottish National Diabetic Retinopathy Screening Programme [PDF]

, 2014
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.Peer reviewedPublisher ...
A D Morris, Cheng, D T Cromie, D W M Pearson, Elman, G P Leese, Ghafour, H C Looker, H M Colhoun, Hammes, J A McKnight, J A Olson, J Doig, Klein, Klein, Klein, Kohner, LeCaire, Leese, Leese, Looker, Looker, M W Black, Misra, Murgatroyd, N Lee, Olson, Pandit, Philip, R S Lindsay, Roy, S H Wild, S O Nyangoma, S Philip, Stratton, van Leiden, Zhang   +36 more
core   +7 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Sclerostin Suppression Facilitates Uveal Melanoma Progression Through Activating Wnt/β-Catenin Signaling Via Binding to Membrane Receptors LRP5/LRP6

Frontiers in Oncology, 2022
ObjectiveUveal melanoma (UM) is the most frequent primary eye cancer in adults with a 50% mortality rate. Characterizing the fundamental signaling pathways that drive UM is of importance for the development of targeted therapy.
Hanqing Wang, Hanqing Wang, Sidi Zhao, Yang Liu, Fengyuan Sun, Fengyuan Sun, Xiaoming Huang, Xiaoming Huang, Tong Wu, Tong Wu   +9 more
doaj   +1 more source

The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options. [PDF]

, 2020
Homeostasis of the lacrimal functional unit is needed to ensure a well-regulated ocular immune response comprising innate and adaptive phases. When the ocular immune system is excessively stimulated and/or immunoregulatory mechanisms are disrupted, the ...
Lin, Meng C, Neri, Piergiorgio, Perez, Victor L, Periman, Laura M, Saban, Daniel R   +4 more
core   +1 more source

Toward Developing Models to Study the Disease, Ecology, and Evolution of the Eye in Mollusca [PDF]

, 2008
Several invertebrate systems have been developed to study various aspects of the eye and eye disease including Drosophila, Planaria, Platynereis, and most recently, the cubozoan jellyfish Tripedalia; however, molluscs, the second largest metazoan phylum,
Serb, Jeanne, Serb, Jeanne
core   +3 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source