Results 31 to 40 of about 3,144,487 (302)
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Heritable dog eye diseases [PDF]
, 2013 Object and tasks of work: Object - analyse heritable eye dog diseases. Tasks: analyse literature about dog genetic eye diseases, heritability, clinical sighns; analyse incidence and spectrum of dog genetic eye diseases in different veterinary clinics ...
Valauskaitė, Giedrė
core
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
Genes and genetics in eye diseases: a genomic medicine approach for investigating hereditary and inflammatory ocular disorders [PDF]
International Journal of Ophthalmology, 2018 Past 25y have witnessed an exponential increase in knowledge and understanding of ocular diseases and their respective genetic underpinnings. As a result, scientists have mapped many genes and their variants that can influence vision and health of our ...
Mahavir Singh, Suresh C Tyagi
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Ultrasonography and Postmortem Magnetic Resonance Imaging of Bilateral Ocular Disease in a Heifer
RuminantsBovine ocular diseases are typically characterized by the concurrent appearances of both macroscopic and intraocular abnormalities. This study examines the diagnostic efficacy of a combination of ultrasonography and magnetic resonance imaging (MRI) for ...
Takeshi Tsuka +4 more
doaj +1 more source
Towards the matter of genetic consulting in various forms of congenital and hereditary eye diseases
Офтальмохирургия, 2016 Purpose. To evaluate the results in genetic consulting of patients with various forms of congenital and hereditary eyes pathology.Material and methods.
B. E. Malyugin +7 more
doaj +1 more source
Prime Editing for Human Gene Therapy: Where Are We Now?
Cells, 2023 Gene therapy holds tremendous potential in the treatment of inherited diseases. Unlike traditional medicines, which only treat the symptoms, gene therapy has the potential to cure the disease by addressing the root of the problem: genetic mutations.
Kelly Godbout, Jacques P. Tremblay
doaj +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source