Results 211 to 220 of about 1,116,302 (280)

Dual‐line Genome‐scale CRISPR Screening Enables Robust Target Gene Discovery

Advanced Science, EarlyView.
A species‐optimized CRISPR platform integrates efficient piggyBac delivery, genome‐scale sgRNA libraries, and parallel screening in two independently engineered Bactrocera dorsalis Cas9 cell lines. Cross‐line consensus analysis filters line‐specific effects, enriches candidates with reproducible in vivo phenotypes, and reveals conserved, species ...
Ziniu Li, Jiao Qiao, Qiuyuan Zhang, Peipei Liu, Chenjun Zheng, Qi Zhou, Mengqi Ji, Zhihui Zhu, Xiaoxue Li, Hongyu Zhang   +9 more
wiley   +1 more source

The new bilastine eye drop formulation protects against conjunctival dehydration and promotes corneal wound healing in a comparative in vitro study. [PDF]

Sci Rep
Arana E, Gonzalo A, Andollo N, Pérez-Garrastachu M, Otero-Espinar F, Díaz-Tomé V, Goñi-de-Cerio F, Gómez-Fernández P, Hernández G, Suárez-Cortés T.   +9 more
europepmc   +1 more source

Van der Waals Heterostructures for Next‐Generation Spintronics: Multiferroic‐Mediated Magnetoelectric Properties

Advanced Science, EarlyView.
As CMOS technology approaches fundamental energy limits, new paradigms for low‐power information processing are required. Magnetic systems are attractive for their spin transport, yet current‐induced magnetization control is energy inefficient. Multiferroic heterostructures enable energy‐efficient electric field manipulation of magnetism.
Donghyeon Lee, Jiwoong Yang, Inhyeok Oh, Sanghan Lee   +3 more
wiley   +1 more source

A phase III study comparing preservative-free latanoprost eye drop emulsion with preserved latanoprost in open-angle glaucoma or ocular hypertension. [PDF]

Eye (Lond)
Baudouin C, Stalmans I, Bourne R, Larrosa JM, Schmickler S, Seleznev A, Oddone F, Phase III study group.   +7 more
europepmc   +1 more source

Klotho‐Derived Peptide 1 Protects against Acute Kidney Injury by Directly Targeting Mitochondrial ATAD3A

Advanced Science, EarlyView.
This study uncovers that KP1, a Klotho‐derived peptide, protects the kidney against acute kidney injury, a clinical syndrome with high morbidity and mortality. KP1 enters tubular epithelial cells via endocytosis, directly interacts with the mitochondrial ATAD3A/HIGD2A complex, thereby preventing cytochrome c release, and caspases activation, and ...
Xiaoyao Zhang, Shihui Lin, Tianyu Wu, Zhixin Zhang, Hong Zhou, Xue Hong, Youhua Liu   +6 more
wiley   +1 more source

High‐Pressure Modulation of Breathing Kagome Lattice: Cascade of Lifshitz Transitions and Evolution of the Electronic Structure

Advanced Science, EarlyView.
External pressure directly tunes the breathing distortion of the kagome lattice in Fe3Sn2, suppressing it near 15 GPa and reversing it at higher pressures. This structural modulation drives a cascade of Lifshitz transitions, reconstructs the Fermi surface, strengthens electronic correlations and carrier localization, and modifies ultrafast electron ...
Marcos Vinicius Gonçalves‐Faria, Maxim Wenzel, Yuk Tai Chan, Olga Iakutkina, Francesco Capitani, Davide Comboni, Michael Hanfland, Qi Wang, Hechang Lei, Martin Dressel, Alexander A. Tsirlin, Alexej Pashkin, Stephan Winnerl, Manfred Helm, Ece Uykur   +14 more
wiley   +1 more source

Eye Drop with Fas-Blocking Peptide Attenuates Age-Related Macular Degeneration. [PDF]

Cells
Yi Y, Pyun SH, Kim CY, Yun G, Kang E, Heo S, Ullah I, Lee SK.   +7 more
europepmc   +1 more source

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

Myopia Controlling using Low Dose Atropine Eye Drop. [PDF]

J Curr Ophthalmol
Rajavi Z, Kheiri B, Sheibani K, Sabbaghi H.   +3 more
europepmc   +1 more source

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

Advanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen, Zong Chen, Chenzhi Lai, Yingying Yue, Tian He, Hao Gong, Jing Shi, Xiaoshuang Guo, Yu Wang, Guodong Song, Xiaolei Jin   +10 more
wiley   +1 more source