Results 41 to 50 of about 1,564,095 (245)

The clinical effectiveness and cost-effectiveness of second-eye cataract surgery: a systematic review and economic evaluation [PDF]

, 2014
Background: Elective cataract surgery is the most commonly performed surgical procedure in the NHS. In bilateral cataracts, the eye with greatest vision impairment from cataract is operated on first.
Jonathan Shepherd, Frampton, Geoff, Geoff Frampton, Petra Harris, Harris, Petra, Andrew Lotery, Keith Cooper, Cooper, Keith, Shepherd, Jonathan, Lotery, Andrew J.   +9 more
core   +1 more source

Orbital sparganosis in an 8-year boy: a case report

BMC Ophthalmology, 2018
Background Sparganosis is one of the neglected but important food-borne parasitic zoonoses, with higher prevalence in Asian countries. The infection is commonly located in the subcutaneous tissue, brain, breast, and lung, but fewer reported infections ...
Xin Xie, Jianghua Hu, Guizhen Sun, Bo Ding, Lei Feng   +4 more
doaj   +1 more source

Helminth egg analysis platform (HEAP): An opened platform for microscopic helminth egg identification and quantification based on the integration of deep learning architectures

Journal of Microbiology, Immunology and Infection, 2022
Background: Millions of people throughout the world suffer from parasite infections. Traditionally, technicians use manual eye inspection of microscopic specimens to perform a parasite examination.
Chi-Ching Lee, Po-Jung Huang, Yuan-Ming Yeh, Pei-Hsuan Li, Cheng-Hsun Chiu, Wei-Hung Cheng, Petrus Tang   +6 more
doaj   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Recent large-scale philophthalmosis outbreak in Portugal: inefficacy of common antihelminthic agents

Parasites & Vectors, 2022
Background Parasitic conjunctivitis caused by Philophthalmus spp. is a common ophthalmic disease in birds, with localized outbreaks occurring worldwide.
Petr Heneberg, María Casero
doaj   +1 more source

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Effects of hygiene and defecation behavior on helminths and intestinal protozoa infections in Taabo, Côte d'Ivoire [PDF]

, 2013
Effect of community-led total sanitation and hygiene education to reduce the transmission of helminthiases and intestinal protozoa ...
Silué, Kigbafori D., Kouadio, Bernadette A., Eveline Hürlimann, Bassirou Bonfoh, Clarisse Houngbedji, Utzinger, Jürg, Yapi, Richard B., Kouassi Dongo, Kouadio Bernadette A., N’Goran Eliézer K., Utzinger Jürg, Richard B Yapi, Houngbedji Clarisse, Zouzou, Fabien, Dongo Kouassi, Bonfoh Bassirou, N'goran, Eliézer K., Jürg Utzinger, Houngbedji, Clarisse, Giovanna Raso, Ouattara Mamadou, Raso, Giovanna, Hürlimann Eveline, Kouassi, Dongo, Acka-Douabélé, Cinthia A., Bonfoh, Bassirou, Fabien Zouzou, Schmidlin, Thomas, Mamadou Ouattara, Cinthia A Acka-Douabélé, Yapi Richard B., Thomas Schmidlin, Bernadette A Kouadio, Silué Kigbafori D., Acka-Douabélé Cinthia A., Eliézer K N'Goran, Schmidlin Thomas, Ouattara, Mamadou, Hürlimann, Eveline, Kigbafori D Silué, Zouzou Fabien, Raso Giovanna   +41 more
core   +2 more sources

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source