Results 21 to 30 of about 214,065 (255)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Increased choroidal thickness in patient with high-altitude retinopathy

Indian Journal of Ophthalmology, 2014
We report a case of high-altitude retinopathy with increased choroidal thickness detected by spectral-domain optical coherence tomography (SD-OCT). A 36-year-old Japanese man developed an acute vision decrease in his left eye after he had trekked at an ...
Kyoko Hirukawa-Nakayama, Akito Hirakata, Kaoru Tomita, Tomoyuki Hiraoka, Makoto Inoue   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Genetic variations of IL10 and IL6R genes in acute anterior uveitis in Han Chinese

BMC Ophthalmology
Background Several autoimmune disorders have been linked to polymorphisms in IL10 and IL6R genes. This research aimed to study whether single nucleotide polymorphisms (SNPs) in the genes of IL10 and IL6R were associated with acute anterior uveitis (AAU ...
Lin Li, Fuzhen Li, Jiankang Shan, Kunpeng Xie, Pengyi Zhou, Haiyan Zhu, Xuemin Jin, Liping Du, Peizeng Yang   +8 more
doaj   +1 more source

The quantitative measurements of choroidal thickness and volume in diabetic retinopathy using optical coherence tomography and optical coherence tomography angiography; correlation with vision and foveal avascular zone

BMC Ophthalmology, 2022
Background To represent choroidal thickness (CT) and choroidal volume (CV) databases in diabetic retinopathy (DR) patients and healthy control participants using optical coherence tomography (OCT) and enhanced depth imaging OCT (EDI-OCT).
Fariba Ghassemi, Sahar Berijani, Ameneh Babeli, Houshang Faghihi, Alireza Gholizadeh, Siamak Sabour   +5 more
doaj   +1 more source

Characteristics of eye injuries, medical cost and return-to-work status among industrial workers: a retrospective study

BMJ Open, 2022
Objective The aim of this study is to determine the characteristics of eye injuries, medical costs and return-to-work status among industrial workers to provide better vision rehabilitative services.Setting Nationwide data from the Social Security ...
Rokiah Omar, Nur Syamilah Anan, Izmel Azim Azri, Chiranjib Majumder, Victor Feizal Knight   +4 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Computational pharmacovigilance of Lifitegrast in dry eye disease using machine learning and network toxicology

npj Digital Medicine
Lifitegrast, as a novel therapeutic agent for dry eye disease (DED), has garnered considerable clinical attention, yet the prediction and risk assessment of its adverse drug events (ADEs) remain methodologically challenging.
Lin Li, Shixiang Jing, Xuhua Zhao, Xinyue Zhu, Chunyu Liang, Leite Shi, Pengyi Zhou, Kunpeng Xie, Bo Jin, Haiyan Zhu, Yuying Wang, Xuemin Jin, Liping Du, Peizeng Yang   +13 more
doaj   +1 more source

Ophthalmic masquerades of the atherosclerotic carotids

Indian Journal of Ophthalmology, 2014
Patients with carotid atherosclerosis can present with ophthalmic symptoms. These symptoms and signs can be due to retinal emboli, hypoperfusion of the retina and choroid, opening up of collateral channels, or chronic hypoperfusion of the globe (ocular ...
Anupriya Arthur, Anika Alexander, Simerpreet Bal, Ajith Sivadasan, Sanjith Aaron   +4 more
doaj   +1 more source

EPIDEMIOLOGY OF THE PEDIATRIC EYE INJURIES IN THE SUGHD REGION OF TAJIKISTAN

Паёми Сино, 2020
Objective: To study epidemiology and clinical features of of eye injuries in children in Sughd Region of the Republic of Tajikistan from 1993 up to 2013.
KH.J. KARIM-ZADE, N.A. OCHILZODA, Z.A. DADОBOEV   +2 more
doaj   +1 more source