Results 61 to 70 of about 1,715,675 (251)

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu, Changgeng Song, Dianwei Wu, Xiaoqian Niu, Jianmin Hao, Lijuan Liu, Xiaogang Kang, Wen Jiang   +7 more
wiley   +1 more source

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source

Single-cell analysis highlights the role of CD4+ IFN-I-related T cells in Behcet’s uveitis during Interferonα-2a therapy

Biology Direct
Background Behcet’s disease (BD) involves multiple immune cells, but the mechanism by which interferon α-2a (IFNα-2a) exerts therapeutic effects on BD through immune cell modulation remains unclear. This study aimed to investigate the role of CD4 + IFN-I-
Meiqi Wang, Deyu Zhang, Xue Huang, Zhenyu Zhong, Qingfeng Wang, Huan Liu, Guannan Su, Shixiang Jing, Tao Yang, Na Li, Peizeng Yang   +10 more
doaj   +1 more source

Spheniodal mucocele causing bilateral optic neuropathy and ophthalmoplegia

Indian Journal of Ophthalmology, 2014
Sphenoid sinus mucocele comprises only 2% of all paranasal sinus mucoceles. In literature, there is a case report on sphenoidal mucocele causing bilateral optic neuropathy, with unilateral partial recovery and cranial nerve palsy, but we did not come ...
Ambika Selvakumar, Balasubramanyam Mahalaxmi, V Ananth, Cugati Gautam   +3 more
doaj   +1 more source

Inebilizumab in AQP4‐Seropositive NMOSD: One‐Year Follow‐Up From a Multicenter, Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Real‐world evidence on inebilizumab among neuromyelitis optica spectrum disorder (NMOSD) patients is lacking. This study assessed inebilizumab among Chinese patients with aquaporin 4 autoantibody (AQP4‐IgG)‐seropositive NMOSD in a real‐world setting.
Mengcui Gui, Jiayang Zhan, Wei Li, Tao Jin, Dan He, Daishi Tian, Zhijun Li, Jing Lin, Yue Li, Hongyu Zhou, Bitao Bu   +10 more
wiley   +1 more source

Papillary and peripapillary vascular densities and corresponding correlation with peripapillary retinal thicknesses using optical coherence tomography angiography in healthy children and adolescents

Scientific Reports
To evaluate the peripapillary retinal thickness (PPRT), vascular density (PPVD), and disc vascular density (PVD) and their correlations in normal healthy children using optical coherence tomography angiography (OCTA).
Fariba Ghassemi, Farhad Salari, Vahid Hatami, Masoumeh Mohebbi, Siamak Sabour   +4 more
doaj   +1 more source

Prognostic Indicators for No Light Perception After Open-Globe Injury: Eye Injury Vitrectomy Study

, 2011
PURPOSE: To describe ocular characteristics, surgical interventions, and anatomic and visual outcomes of traumatized eyes with no light perception (NLP) following open-globe injury and to investigate prognostic predictors for NLP cases after open-globe ...
Yun Tao Hu, Feng, Kang, Hu, Yun Tao, Zhizhong Ma, Kang Feng, Ma, Zhizhong   +5 more
core   +1 more source

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu, Jie Ding, Yupeng Du, Guibao Luo, Jinming Li, Rui Liu, Xiaoyi Xu, Xiao Li, Minshu Li, Wei Jiang, Chunsheng Yang   +10 more
wiley   +1 more source

The influence of insulin on diabetic retinopathy and retinal vessel parameters in diabetes

Diabetology & Metabolic Syndrome
Aim To investigate the associations between insulin use and diabetic retinopathy (DR), and retinal vascular parameters in type 2 diabetes (T2DM). Methods A total of 6,374 T2DM patients, consisting of 2,231 patients receiving insulin alone and 4143 ...
Tianyi Yuan, Senlin Lin, Yi Xu, Lina Lu, Minna Cheng, Yuheng Wang, Qinping Yang, Saiguang Ling, Dengji Zhou, Yan Shi, Haidong Zou, Yingyan Ma   +11 more
doaj   +1 more source

CD4 positive T helper cells contribute to retinal ganglion cell death in mouse model of ischemia reperfusion injury

, 2013
Neuron degeneration is a common pathological process associated with many disease conditions in the central nervous system including retina. Although immune responses have been proposed as one potential element in triggering neural damage, the mechanism ...
Huo, Yanjiao, Huang, Ping, Li, Hong, Zhang, Samuel S., Zhang, Chun, Lou, Lucy X., Barnstable, Colin J.   +6 more
core   +1 more source