Results 41 to 50 of about 106,088 (256)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Data free knowledge distillation with feature synthesis and spatial consistency for image analysis

Scientific Reports
Privacy and security concerns restrict access to original training datasets, posing significant challenges for model compression. Data-Free Knowledge Distillation (DFKD) emerges as a solution, aiming to transfer knowledge from teacher to student networks
Pengchen Liang, Jianguo Chen, Yan Wu, Bin Pu, Haishan Huang, Qing Chang, Guo Ran   +6 more
doaj   +1 more source

Optic Disc Melanocytoma: A Case Report and Review

Journal of Pediatrics Review, 2021
Introduction: Melanocytoma is a rare benign stationary tumor that usually appears as a pigmented lesion on the optic disk. Optic Disc Melanocytoma (ODM) can compress the optic nerve or undergo necrosis, leading to ischemic axonal loss and visual field ...
Ali Ahmadzadeh Amiri, Majid Reza Sheikhrezaee, Ahmad Ahmadzadeh Amiri   +2 more
doaj  

Squamous Cell Carcinoma Involving Periocular Area [PDF]

Journal of Clinical and Diagnostic Research, 2019
Squamous Cell Carcinoma (SCC) involving periocular area accounts for 5-10% of all malignant eyelid neoplasms. Although, periocular SCC is the second most common eyelid malignancy after basal cell carcinoma, but is more aggressive and invasive than basal ...
Madhumita Rout, Zahiruddin Khan, Lipika Panda   +2 more
doaj   +1 more source

Magnesium‐Based Transient Bioelectronics, Bio‐Optics and Bio‐Scaffolds

Advanced Functional Materials, EarlyView.
This paper reviews the state of the art and recent advances in magnesium‐based thin‐film, foils, and scaffolds for applications in transient bio‐optics, bioelectronics and tissue engineering. The design principles, fabrication methods, material properties, and integration strategies are discussed in detail.
Massimo Mariello, Yves Leterrier
wiley   +1 more source

Retrobulbar chondrosarcoma in a dog [PDF]

Open Veterinary Journal, 2014
This paper presents a review of a dog, with a retrobulbar chondrosarcoma, which was admitted for surgery for visible changes in his eye during inspection. Orbital neoplasia in dogs may be primary and secondary.
M. Ralić, J. Vasić, M. Jovanović, B. Cameron   +3 more
doaj  

[Metastatic neoplasms of the eye].

Klinika oczna, 1990
Metastatic neoplasms of the eye ball and their clinical picture, diagnosis, treatment and prognosis and discussed.
S, Sporny, J, Szwalski
openaire   +1 more source

Electrostatically‐Stabilized PEG‐Free Lipid Nanoparticles for Systemic Nucleic Acid Delivery

Advanced Functional Materials, EarlyView.
This work describes non‐PEGylated layered lipid nanoparticles (nonPEG LLNPs), a gene delivery platform that improves upon standard PEGylated LNPs via electrostatic adsorption of charged polymers. nonPEG LLNPs maintain colloidal stability under biological stresses, enhance circulation time, and mitigate accelerated blood clearance and hepatic ...
Namita Nabar, Deeksha Kumaresh, Eduardo Nombera Bueno, Mae Pryor, Paula T. Hammond   +4 more
wiley   +1 more source

Two Cases of Severe Hypertension in JAK2 Mutation-Positive Myeloproliferative Neoplasms

Case Reports in Vascular Medicine, 2020
Background. Myeloproliferative neoplasms are a heterogeneous group of disorders resulting from the abnormal proliferation of one or more terminal myeloid cells—established complications include thrombosis and haemorrhagic events; however, there is ...
Raunak Rao, Spoorthy Kulkarni, Ian B. Wilkinson   +2 more
doaj   +1 more source