Results 61 to 70 of about 90,737 (168)

A Dual Approach Combining Metal‐Organic Frameworks and Commercial Solid‐Phase Microextraction Coatings for Monitoring Volatiles in Passion Fruit

Journal of Separation Science, Volume 49, Issue 9, September 2026.
A CIM‐80(Al) metal‐organic framework coating is proposed for the untargeted analysis of passion fruit juices using either headspace or direct immersion solid‐phase microextraction coupled with gas chromatography‐mass spectrometry. The CIM‐80(Al)‐coated fiber enabled the annotation of 14 unique compounds not detected with commercial fibers.
Montse Saura‐Cayuela, Martina Rosso, Cecilia Cagliero, Jorge Pasán, Juan H. Ayala, Verónica Pino, María J. Trujillo‐Rodríguez   +6 more
wiley   +1 more source

Iso‐ and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On‐Target Activity Through Scaffold Decoration and In Situ Warhead Generation

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
We explore covalent allosteric targeting of MGL regulatory cysteines using iso‐ and benzisothiazolinone scaffolds. Combining mechanism‐based warhead release with structure‐guided scaffold decoration to improve molecular recognition, this study probes strategies to achieve selective on‐target engagement beyond the catalytic site. Monoacylglycerol lipase
Edoardo Rocca, Annalida Bedini, Laura Scalvini, Francesca Galvani, Riccardo Castelli, Lorenzo Sarcone, Adriano Recchia, Fabiola Fanini, Adren Tran, Silvia Rivara, Gilberto Spadoni, Daniele Piomelli, Marco Mor   +12 more
wiley   +1 more source

Sensitive and rapid titrimetric and spectrophotometric methods for the determination of stavudine in pharmaceuticals using bromate-bromide and three dyes

Anais da Academia Brasileira de Ciências, 2008
Four sensitive and rapid methods for the determination of stavudine (STV) in bulk drug and in dosage forms were developed and optimized. In titrimetry, aqueous solution of STV was treated with a known excess of bromate-bromide in HCl medium followed by ...
Kanakapura Basavaiah, Veeraiah Ramakrishna, Chikkaswamy Somashekar, Urdigere R. Anil Kumar   +3 more
doaj   +1 more source

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti, Elisa Patacchini, Emanuele Cara, Laura Zarbo, Antonella Messore, Aurora Albano, Giuseppe Ruggieri, Valentina Noemi Madia, Luigi Scipione, Roberta Costi, Roberto Di Santo   +10 more
wiley   +1 more source

Tratamiento farmacológico de la obesidad

Revista Médica Clínica Las Condes, 2012
Para un porcentaje alto de pacientes que no logran controlar su peso solo con modificación de su hábito de alimentación y ejercicio se hace necesario contar con fármacos que apoyen los cambios de estilo de vida.
Álvarez V. Verónica, Dra.
doaj   +1 more source

Noninnocent Deep Eutectic Solvents Enable Selective, Sustainable Nickel‐Catalyzed Cross‐Electrophile Couplings to Diarylmethanes

ChemSusChem, Volume 19, Issue 16, 27 August 2026.
Ni‐catalyzed cross‐electrophile coupling (XEC) of aryl iodides with benzyl chlorides proceeds efficiently in the deep eutectic solvent (DES) choline chloride/urea, replacing hazardous amide solvents. Under mild, aerobic, heterogeneous conditions, diarylmethanes form in up to 95% yield.
Andrea Nicola Paparella, Maristella Simone, Alessia Battezzato, Laura Chevet, Laetitia Chausset‐Boissarie, Muriel Durandetti, Filippo Maria Perna, Vito Capriati   +7 more
wiley   +1 more source

INFLUÊNCIA DE FÁRMACOS SOBRE A FORMAÇÃO DE ÚLCERAS POR PRESSÃO: REVISÃO INTEGRATIVA

Revista Enfermagem Contemporânea, 2016
Objetivo: objetivou-se caracterizar a produção científica acerca da influência de fármacos sobre a formação de úlceras por pressão (UPP). Método: foi realizada uma revisão integrativa, de abordagem qualitativa, no SciELO, BDENF e LILACS. Utilizando-se os
Ana Fabia Salgado de Almeida, Tallyta Sales Bezerra Soares, Rita Neuma Dantas Cavalcante de Abreu, Francisco Antonio da Cruz Mendonça, Marilene Alves Oliveira Guanabara, Luis Rafael Leite Sampaio   +5 more
doaj   +1 more source

Palladium‐Catalyzed Alkynylation of Allylic Carbonates With Terminal Alkynes: Stereoretentive Access to 1,4‐Enynes and Diarylalkenyl Propargylic Frameworks

Advanced Synthesis &Catalysis, Volume 368, Issue 16, 18 August 2026.
A palladium‐catalyzed alkynylation of cinnamyl carbonates with terminal alkynes provides efficient and stereoretentive access to 1,4‐enynes, enabling the synthesis of challenging diarylalkenyl propargylic frameworks. A mild and efficient palladium‐catalyzed alkynylation of 3‐aryl, 3,3‐diaryl, and aliphatic allylic carbonates with terminal alkynes has ...
Yuri Gazzilli, Antonella Goggiamani, Federico Marrone, Francesco Stipa, Ilaria Ambrogio, Alessandro Carlone, Giancarlo Fabrizi, Antonia Iazzetti   +7 more
wiley   +1 more source

Polirradiculoneuropatia periférica desmielinizante associada ao uso de carbamazepina em cão: relato de caso

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
RESUMO Diversos fármacos são utilizados no tratamento da epilepsia e, assim como outros medicamentos, podem induzir a ocorrência de efeitos adversos, alguns tão graves que geram a necessidade de descontinuidade e substituição da terapia.
S.M. Caramalac, S.M. Caramalac, T.D. Fernandes, M.I.P. Palumbo   +3 more
doaj   +1 more source

Real‐World Treatment Patterns and Physician Perspectives in Relapsed/Refractory Multiple Myeloma: Results From a Nationwide Italian GIMEMA Survey

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT Background The management of relapsed/refractory multiple myeloma (RRMM) remains complex due to early exposure to multiple drug classes since the first treatment line. Aims To evaluate treatment patterns and identify unmet clinical needs in RRMM across Italian hematology centers.
Francesca Fazio, Alfonso Piciocchi, Paolo de Fabritiis, Messina Messina, Stefano Soddu, Valeria Sargentini, Francesco Di Raimondo, Francesca Patriarca, Pellegrino Musto, Maurizio Offidani, Elena Zamagni, Sara Bringhen, Massimo Gentile, Giuseppe Mele, Paola Fazi, MariaTeresa Petrucci, Michele Cavo   +16 more
wiley   +1 more source