Results 141 to 150 of about 373,254 (241)
Advanced Science, EarlyView.Full androgen deprivation (FAD) induces paracrine cholesterol in prostate cancer that drives the polarization of cancer‐associated fibroblasts (CAFs) and subsequent elevated matrix stiffness. Matrix stiffness in turn potentiates tumor cell survival under FAD pressure via dual mechanotransductive activation of the IRE1α‐XBP1s stress‐response axis ...
Shaojie Liu +20 more
wiley +1 more source
Dual-ligand-modified cantharidin nanoparticles for the treatment of hepatocellular carcinoma via the inhibition of Ephb4. [PDF]
Drug DelivJiang W +6 more
europepmc +1 more source
Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor
Advanced Science, EarlyView.The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao +11 more
wiley +1 more source
Upcycling Municipal Solid Incineration Fly Ash into Layered Double Hydroxide Nanomaterials: Heavy Metal Immobilization and Environmental Risk Assessment. [PDF]
Nanomaterials (Basel)Zhao Y, Wang X, Zhang Z, Xu M.
europepmc +1 more source
Chico Bastidores: Na voz dos fãs
, 2013 Este artigo analisa a estratégia de marketing online desenvolvida para o lançamento de Chico, o novo CD do cantor e compositor brasileiro Chico Buarque de Holanda e a adesão dos fãs ao projeto na Internet. Os pontos de estudo são a plataforma interativa Chico Bastidores e a repercussão do projeto na voz dos fãs.
openaire +1 more source
Adaptive Coordination Engineering for Efficient and Robust H2 Release
Advanced Science, EarlyView.β‐H elimination is a pivotal but challenging step in homogeneous formic acid dehydrogenation reactions due to strict hydride‐metal matching. By using a rationally designed Pd1Ag2 bimetallic system with adaptive Pd1‐Ag2/L2 coordination and formate bridges, it enables boosted formic acid dehydrogenation under ambient air (7.7 times higher than a Pd ...
Xiaolin Jiang +8 more
wiley +1 more source
Advanced Science, EarlyView.ABSTRACT High‐fat diet (HFD)‐induced hepatic injury represents a pathology observed across vertebrates, yet the underlying mechanisms remain incompletely understood. Herein, the present study identifies phosphatidylethanolamine methyltransferase (Pemt), a key enzyme in phosphatidylcholine synthesis, as a critical regulator of mitochondrial homeostasis ...
Xianyong Bu +11 more
wiley +1 more source