Results 71 to 80 of about 173,176 (244)

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

História e música : tecendo memórias, compondo identidades [PDF]

, 2007
Neste espaço de reflexão, procura-se edificar um breve painel dos trabalhos que têm se voltado à música como objeto de estudo, privilegiando aqueles estudiosos com os quais o grupo de pesquisa que coordeno tem procurado manter uma interlocução.
Brito, Eleonora Zicari Costa de
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Material‐Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells

Advanced Science, EarlyView.
Tuning cell and cytoskeleton mechanics modulated nuclear shape and heterochromatin organization in ASCs. Distinct cytoskeletal architectures induced nuclear morphologies from oblate to prolate ellipsoids. Large elongated cells with a structured actin cap exhibited high nuclear strain, driving nuclear envelope deformation and heterochromatin ...
Carlo F. Natale, Luca Messina, Valeria Panzetta, Stefania Saporito, Costantino Menna, Maurizio Ventre, Paolo A. Netti   +6 more
wiley   +1 more source

The Imperative of Systems Thinking Approach in Driving Food Systems Transformation through Science and Innovation

The Proceedings of the Nigerian Academy of Science
As the world became progressively aware that increasing production did not solve global hunger and health problems, the issue of the environmental and social costs of focusing solely on food security and nutrition came to the fore. The term ‘food systems
Olanike K. Adeyemo FAS
doaj   +1 more source

Crowdfunding como modelo de financiamento alternativo para o jornalismo de investigação: o case study Português do I Fund News [PDF]

, 2015
A crise que se abateu desde há vários anos sobre o jornalismo de investigação, cujas origens se devem, principalmente, a razões financeiras, conduziu a uma diminuição drástica de recursos humanos nas redações, levando a uma consequente quebra do ...
Diz, Henrique, Dos Santos, Maria José Palma Lampreia, Fonseca, Ana Maria   +2 more
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Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Referencial de educação para os media para a educação pré-escolar, o ensino básico e o ensino secundário [PDF]

, 2014
(Excerto) A Educação para os Media é um processo pedagógico que procura capacitar os cidadãos para viverem de forma crítica e interventiva a “ecologia comunicacional” dos nossos dias.
Guedes, Madalena, Madureira, Eduardo Jorge, Pedroso, José Vítor, coord., Pereira, Sara, Pinto, Manuel, Pombo, Teresa, Santos, Luís Filipe, coord.   +6 more
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Lipid‐Facilitated Opening of the ADAM10 Sheddase Revealed by Enhanced Sampling Simulations

Advanced Science, EarlyView.
Phosphatidylserine acts as a lipid trigger to enhance activation of the sheddase ADAM10. By integrating fluorescence spectroscopy assays with enhanced sampling molecular dynamics simulations, this study shows that phosphatidylserine promotes ADAM10 catalytic activity along with expansion of its extracellular domains, enhancing accessibility to scaffold
Adrien Schahl, Nandan Haloi, Marta Carroni, Shengpan Zhang, Quentin James Sattentau, Erdinc Sezgin, Lucie Delemotte, Rebecca J. Howard   +7 more
wiley   +1 more source

Non-apoptotic Fas (CD95) Signaling on T Cells Regulates the Resolution of Th2-Mediated Inflammation

Frontiers in Immunology, 2018
Fas (CD95/APO-1) and its ligand (FasL/CD95L) promote the resolution of type 2 lung inflammation and eosinophilia. We previously found that Fas-deficiency on T cells, but not eosinophils, delayed resolution of inflammation.
Jesse W. Williams, Caroline M. Ferreira, Kelly M. Blaine, Crystal Rayon, Francisco Velázquez, Jiankun Tong, Marcus E. Peter, Anne I. Sperling, Anne I. Sperling, Anne I. Sperling   +9 more
doaj   +1 more source

Tribal Marketing: portuguese adaptation and preliminary psychometric results of tribalism, team brand loyalty, team brand value and personal/group identity questionnaire [PDF]

, 2017
O objetivo deste estudo foi adaptar para a população portuguesa e validar as características psicométricas preliminares do questionário de Tribalismo de Rudi Meir, Lealdade Marca-Equipa, Valor Marca e Identidade pessoal/grupo. Foi seguido um protocolo de
Almeida, H. M. R., Bem-Haja, P., Silva, C., Simões, D.   +3 more
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