DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis
Advanced Science, EarlyView.This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li +25 more
wiley +1 more source
Description of the femur of Protomegalonyx chasicoensis Scillato-Yané (Mammalia, Xenarthra, Megalonychidae) from the arroyo Chasicó Formation (Late Miocene): systematic consideration on the sloths of chasicóan age [PDF]
, 2009 Se realiza la descripción del fémur del perezoso Protomegalonyx chasicoenis Scillato-Yané sobre la base de un fémur derecho completo (MMP M 478) procedente de la Formación Arroyo Chasicó (Mioceno tardío), en el sudoeste de la provincia de Buenos Aires ...
Brandoni, Diego
core
A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes
Advanced Science, EarlyView.We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen +13 more
wiley +1 more source
Avaliação das tensões numa prótese do fémur sob influência de diferentes materiais (Stresses assessment in a femoral prosthesis under the influence of different materials) [PDF]
, 2011 O principal objectivo deste trabalho é avaliar o comportamento biomecânico na utilização de diferentes materiais numa prótese do fémur. Pretende-se assim avaliar a resistência biomecânica do conjunto osso-implante, através da distribuição de tensões e ...
Fonseca, E.M.M. +2 more
core
Advanced Science, EarlyView.Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu +9 more
wiley +1 more source
New design of a patello-femoral prosthesis [PDF]
, 2010 Este artigo descreve as patologias do joelho passíveis de serem tratadas com próteses patelofemorais bem como as deficiências mais comuns das próteses disponíveis no mercado e propõe o desenvolvimento de uma prótese com novo design que venha a ...
Cameron, Eliomar
core
Advanced Science, EarlyView.The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan +16 more
wiley +1 more source
Peritaje arbitral de una fractura del cuello del fémur por accidente de trabajo
Cirugía del Uruguay, 2019 Sesión del 27 de Setiembre de 1933.
Domingo Prat
doaj
Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration
Advanced Science, EarlyView.Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman +5 more
wiley +1 more source
Exostose géante de l'extrémité inférieure du fémur
The Pan African Medical Journal, 2014 Les exostoses sont des formations osseuses développées à la surface des os et qui sont recouvertes par du cartilage. Il s'agit de la plus fréquente des tumeurs bénignes après les fibromes non ossifiant et les lacunes métaphysaires.
Younes Ouchrif, Issam Elouakili
doaj +1 more source