Results 101 to 110 of about 202,449 (245)
Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis
Advanced Science, EarlyView.Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason +12 more
wiley +1 more source
Ortesis para la prevención de la subluxación y luxación de rodilla en alargamientos femorales complejos [PDF]
, 1995 Se describe una ortesis para uso en la prevención de la subluxación y luxación de rodilla en los casos de alargamientos femorales en los que se considera posible la presentación de este problemaWe present an orthesis to prevent dislocation of the knee ...
Blasco Mollá, María Carmen +3 more
core
Advanced Science, EarlyView.This study identifies GDF15+ TAMs as a cell subset mediating tumor regression after immunotherapy. Macrophage‐intrinsic GDF15 enhances phagocytosis and antigen cross‐presentation to CD8+ T cells through the NF‐κB signaling pathway, thereby inhibiting tumor progression.
Xinyu Zhou +9 more
wiley +1 more source
Estimación microscópica de edad a partir de la zona cortical del fémur en individuos adultos: revisión metodológica [PDF]
, 2016 The main contribution of quantitative histology to anthropology has been the estimation of age at death in undocumented human skeletal remains. Sequential bone remodeling processes allow us to observe the association between the number of osteons and ...
Desántolo, Bárbara, Inda, Ana María
core
Advanced Science, EarlyView.Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou +6 more
wiley +1 more source
Coxa vara congénita o infantil
Cirugía del Uruguay, 1973 A propósito de la coxa vara infantil se ha expuesto una clasificación etiológica de las coxa vara del niño, que creemos permite orientarse con relativa facilidad frente a los distintos tipos de este síndrome No se está en condiciones aún de afirmar su ...
Heber Motta, Mario Schimchak
doaj
Artroplastia total da anca: Colocação da haste femoral com manutenção dos parafusos de uma osteossíntese antiga [PDF]
, 2005 Apresenta-se o caso de um doente que foi submetido, em 1958, a uma osteotomia de valgização para o tratamento de uma fractura traumática do colo do fémur, tendo sido utilizado um cravo-placa de Mac Laughlin para a osteossíntese da osteotomia.
Costa, P +4 more
core
Advanced Science, EarlyView.ABSTRACT Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single‐nucleotide variants. While the current efficient version of adenine base editors (ABEs), such as ABE8e, exhibits exceptional efficiency for A‐to‐G conversions, their clinical translation is hindered by ...
Jiawei Yao +12 more
wiley +1 more source
Aneurisma infeccioso primario del trípode femoral
Cirugía del Uruguay, 1974 Se presenta una observación de aneurisma infeccioso (micótico) primario del trípode femoral izquierdo aparecido en el curso de una se-psis por Salmonella colerasuis.
Milton Mazza +5 more
doaj