Results 301 to 310 of about 80,011 (352)
Plant, Cell &Environment, Volume 48, Issue 8, Page 5897-5908, August 2025.ABSTRACT The NON‐RACE‐SPECIFIC DISEASE RESISTANCE 1/harpin‐induced 1‐LIKE (NHL) gene family plays pivotal roles, including pathogen resistance, abiotic stress tolerance, and developmental regulation, underscoring their functional versatility in developmental and physiological processes of plants.
Victoria Amato +4 more
wiley +1 more source
Journal of Biomedical Materials Research Part A, Volume 113, Issue 7, July 2025.ABSTRACT Growth factors enhance survival and integration of transplanted Mesenchymal Stromal Cells (MSC), but successful supplementation often requires supraphysiological growth factor doses, risking off‐target effects. Short peptide mimics like the knuckle epitope (KE) of Bone Morphogenetic Protein 2 (BMP‐2) can be covalently immobilized to ...
Sydney Neal +6 more
wiley +1 more source
Double the Double: Revisiting BCL11B's Multimerization
Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 7, Page 1205-1211, July 2025.ABSTRACT The transcription factor B Cell Lymphoma/Leukemia 11B (BCL11B) exerts a bi‐directional function in cancer, with its role as an emerging therapeutic target in cancer treatment being particularly intriguing. BCL11B knockouts in cultured T cells revealed the acquisition of properties characteristic of natural killer cells, hinting at its ...
Anne Susemihl +5 more
wiley +1 more source
Microscopy and spectroscopy approaches to study GPCR structure and function
British Journal of Pharmacology, Volume 182, Issue 14, Page 3090-3108, July 2025.Abstract The GPCR signalling cascade is a key pathway responsible for the signal transduction of a multitude of physical and chemical stimuli, including light, odorants, neurotransmitters and hormones. Understanding the structural and functional properties of the GPCR cascade requires direct observation of signalling processes in high spatial and ...
Tomáš Fessl +2 more
wiley +1 more source
The dark sides of the GPCR tree ‐ research progress on understudied GPCRs
British Journal of Pharmacology, Volume 182, Issue 14, Page 3109-3134, July 2025.Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf +10 more
wiley +1 more source
Arrestin‐centred interactions at the membrane and their conformational determinants
British Journal of Pharmacology, Volume 182, Issue 14, Page 3135-3150, July 2025.Abstract More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling. Originally named for their capacity to hinder GPCR coupling to G proteins and facilitate receptor desensitisation, arrestins have emerged as key hubs for a myriad of
Owen Underwood +3 more
wiley +1 more source
Targeted protein degradation of PDE4 shortforms by a novel proteolysis targeting chimera
The FEBS Journal, Volume 292, Issue 13, Page 3360-3377, July 2025.Here, we report KTX207, a previously undescribed cereblon‐based PDE4 PROTAC that can specifically target PDE4D shortform for degradation. We showed that KTX207 could improve selectivity, potency and enable a long‐lasting effect when used at a sub‐nanomolar concentration.
Yuan Yan Sin +16 more
wiley +1 more source
New Phytologist, Volume 247, Issue 1, Page 128-143, July 2025.Summary The Chl d‐containing cyanobacterium, Acaryochloris marina MBIC11017, is constitutively adapted to far‐red light (FRL). However, it occasionally encounters white light (WL) in its natural habitat. Using biochemical and spectroscopic techniques, we investigated how this organism acclimates to WL and analysed the excitation energy trapping ...
Thomas J. Oliver +2 more
wiley +1 more source
ChemBioChem, Volume 26, Issue 12, June 16, 2025.An expansion of the concept of pseudoglucosinolates (psGSLs) is reported introducing the first azoreductase‐responsive psGSL‐based probe releasing an isothiocyanate under simultaneous fluorescence turn‐on in the presence of AzoR, an azoreductase from Escherichia coli.
Aishi Chakrabarti +13 more
wiley +1 more source
Photoswitching Lanthanoid Luminescence With Diazocines
Chemistry – A European Journal, Volume 31, Issue 32, June 6, 2025.Photomodulation of lanthanoid luminescence promises new layers of complexity for diverse applications. We herein present a new strategy for the manipulation of luminescence intensities and lifetimes based on diazocine photoswitches. This strategy is particularly well suited for multiplexing and does not require covalent connection of individual ...
Nicole Winterholler, Elisabeth Kreidt
wiley +1 more source