Role of the F-BAR Family Member PSTPIP2 in Autoinflammatory Diseases. [PDF]
Front Immunol, 2021 Proline-serine-threonine-phosphatase-interacting protein 2 (PSTPIP2) belongs to the Fes/CIP4 homology-Bin/Amphiphysin/Rvs (F-BAR) domain family. It exhibits lipid-binding, membrane deformation, and F-actin binding activity, suggesting broader roles at the membrane–cytoskeleton interface.
Xu JJ +6 more
europepmc +6 more sources
Phagocytosis is mediated by two-dimensional assemblies of the F-BAR protein GAS7 [PDF]
Nature Communications, 2019 The Bin/Amphiphysin/Rvs167 (BAR) domain superfamily, which includes FCH-BAR (F-BAR) domain proteins are membrane-sculpting proteins. Here the authors combine a range of techniques and show that the F-BAR domain of growth-arrest specific protein 7 (GAS7 ...
Kyoko Hanawa-Suetsugu +19 more
doaj +3 more sources
Modulation of fungal virulence through CRZ1 regulated F-BAR-dependent actin remodeling and endocytosis in chickpea infecting phytopathogen Ascochyta rabiei. [PDF]
PLoS Genetics, 2021 Polarized hyphal growth of filamentous pathogenic fungi is an essential event for host penetration and colonization. The long-range early endosomal trafficking during hyphal growth is crucial for nutrient uptake, sensing of host-specific cues, and ...
Manisha Sinha +6 more
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RNAi Screen in Tribolium Reveals Involvement of F-BAR Proteins in Myoblast Fusion and Visceral Muscle Morphogenesis in Insects [PDF]
G3: Genes, Genomes, Genetics, 2019 In a large-scale RNAi screen in Tribolium castaneum for genes with knock-down phenotypes in the larval somatic musculature, one recurring phenotype was the appearance of larval muscle fibers that were significantly thinner than those in control animals ...
Dorothea Schultheis +2 more
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Endocytosis and membrane receptor internalization: implication of F-BAR protein Carom. [PDF]
Front Biosci (Landmark Ed), 2017 Endocytosis is a cellular process mostly responsible for membrane receptor internalization. Cell membrane receptors bind to their ligands and form a complex which can be internalized. We previously proposed that F-BAR protein initiates membrane curvature and mediates endocytosis via its binding partners.
Xu Y +14 more
europepmc +5 more sources
Membrane sculpting by F-BAR domains studied by molecular dynamics simulations. [PDF]
PLoS Computational Biology, 2013 Interplay between cellular membranes and their peripheral proteins drives many processes in eukaryotic cells. Proteins of the Bin/Amphiphysin/Rvs (BAR) domain family, in particular, play a role in cellular morphogenesis, for example curving planar ...
Hang Yu, Klaus Schulten
doaj +5 more sources
Linking up at the BAR: Oligomerization and F-BAR protein function. [PDF]
Cell Cycle, 2016 As cells grow, move, and divide, they must reorganize and rearrange their membranes and cytoskeleton. The F-BAR protein family links cellular membranes with actin cytoskeletal rearrangements in processes including endocytosis, cytokinesis, and cell motility.
McDonald NA, Gould KL.
europepmc +5 more sources
Small GTPase Cdc42, WASP, and scaffold proteins for higher-order assembly of the F-BAR domain protein. [PDF]
Sci Adv, 2023 The higher-order assembly of Bin-amphiphysin-Rvs (BAR) domain proteins, including the FCH-BAR (F-BAR) domain proteins, into lattice on the membrane is essential for the formation of subcellular structures.
Wan Mohamad Noor WNI +8 more
europepmc +2 more sources
Mechanical loading of intraluminal pressure mediates wound angiogenesis by regulating the TOCA family of F-BAR proteins. [PDF]
Nat Commun, 2022 Angiogenesis is regulated in coordinated fashion by chemical and mechanical cues acting on endothelial cells (ECs). However, the mechanobiological mechanisms of angiogenesis remain unknown.
Yuge S +15 more
europepmc +2 more sources
Optimizing Gō-MARTINI Coarse-Grained Model for F-BAR Protein on Lipid Membrane. [PDF]
Front Mol Biosci, 2021 Coarse-grained (CG) molecular dynamics (MD) simulations allow us to access much larger length and time scales than atomistic MD simulations, providing an attractive alternative to the conventional simulations.
Mahmood MI, Poma AB, Okazaki KI.
europepmc +2 more sources