Results 141 to 150 of about 10,499,655 (247)
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Nature CommunicationsIn this work, we resolve conflicting experimental and theoretical findings related to the dynamical stability and superconducting properties of $$Fm\bar{3}m$$ F m 3 ¯ m -LuH3, which was recently suggested as the parent phase harboring room-temperature ...
Roman Lucrezi +3 more
doaj +1 more source
Early thrombolysis in acute myocardial infarction: limitation of infarct size and improved survival.
Journal of the American College of Cardiology, 1986 M. Simoons +11 more
semanticscholar +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Nilpotent graphs of Lie superalgebras: structure and graph-theoretic properties
AIMS MathematicsWe introduce the nilpotent graph $ \Gamma_N(L) $ of a finite-dimensional Lie superalgebra $ L = L_{\bar{0}} \oplus L_{\bar{1}} $ over a field $ \mathbb{F} $, with vertices consisting of non-nilpotent elements and edges connecting pairs that generate ...
Ali Yahya Hummdi +3 more
doaj +1 more source
The F-BAR protein NOSTRIN in endothelial signal transduction [PDF]
, 2017 NOSTRIN belongs to the family of F-BAR proteins, which are multi-domain adaptor proteins that have emerged as important regulators of membrane remodeling and actin dynamics in a variety of vital cellular processes. They have been analyzed structurally and biochemically and overexpression studies have revealed their potential in inducing membrane ...
openaire
$Z'$ constraints from $e^+e^-\rightarrow f\bar f$ at NLC
, 1996 Constraints on extra neutral gauge bosons are obtained from $e^+e^-\rightarrow f\bar f$ at NLC energies. Model independent limits on the $Z'f\bar f$ couplings and lower limits on the $Z'$ mass are discussed. Typical GUTs with $M_{Z'}$ up to (3 -- 6) $\sqrt{s}$ can be excluded.
Leike, A., Riemann, S.
openaire +2 more sources
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source