Results 171 to 180 of about 12,080,229 (289)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Phosphorylation in the intrinsically disordered region of F-BAR protein Imp2 regulates its contractile ring recruitment.

open access: yesJ Cell Sci, 2021
Willet AH   +10 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

Efficacy of BioMin F and NovaMin toothpastes against streptococcus mutans: an in vitro study

open access: yesBDJ Open
Objective This in vitro study was accomplished to demonstrate the antibacterial efficacy of BioMin F and NovaMin toothpastes against the recently-isolated Streptococcus Mutans in comparison with a commonly used fluoride toothpaste.
Haya Doura Alomari   +2 more
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

A Curved‐Bar Rack‐Bypass System With Innovative Foil Shaped Bars: Hydraulics, Operational Aspects, and Swimming Behavior of Downstream Moving Brown Trout

open access: yesWater Resources Research
Curved bar rack ‐ bypass systems (CBR‐BS) are a promising technology for diverting downstream moving fish away from hydropower intakes. A CBR functions as a mechanical behavioral barrier by creating high velocity and pressure gradients along its bars ...
Fan Yang   +7 more
doaj   +1 more source

DYRK kinase Pom1 drives F-BAR protein Cdc15 from the membrane to promote medial division. [PDF]

open access: yesMol Biol Cell, 2020
Bhattacharjee R   +9 more
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

Registration Brochure: State Bar of Texas Annual Meeting, 2014

open access: yes, 2014
Pamphlet for the State Bar of Texas's Annual Meeting held June 26-27, 2014.
State Bar of Texas
core  

The topology of real suspension singularities of type $f \bar{g}+z^n$

open access: yes, 2012
In this article we study the topology of a family of real analytic germs $F \colon (\mathbb{C}^3,0) \to (\mathbb{C},0)$ with isolated critical point at 0, given by $F(x,y,z)=f(x,y)\bar{g(x,y)}+z^r$, where $f$ and $g$ are holomorphic, $r \in \mathbb{Z}^+$ and $r \geq 2$.
openaire   +3 more sources

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