Results 71 to 80 of about 12,080,229 (289)

Pairwise Intersections and Forbidden Configurations [PDF]

Discrete Mathematics & Theoretical Computer Science, 2005
Let $f_m(a,b,c,d)$ denote the maximum size of a family $\mathcal{F}$ of subsets of an $m$-element set for which there is no pair of subsets $A,B \in \mathcal{F}$ with $|A \cap B| \geq a$, $|\bar{A} \cap B| \geq b$, $|A \cap \bar{B}| \geq c$, and $|\bar{A}
Richard P. Anstee, Peter Keevash
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Simulation of Organic Liquid Product Deoxygenation through Multistage Countercurrent Absorber/Stripping Using CO₂ as Solvent with Aspen-HYSYS: Process Modeling and Simulation

Molecules, 2022
In this work, the deoxygenation of organic liquid products (OLP) obtained through the thermal catalytic cracking of palm oil at 450 °C, 1.0 atmosphere, with 10% (wt.) Na2CO3 as a catalyst, in multistage countercurrent absorber columns using supercritical
Manoel Raimundo dos Santos Junior, Elinéia Castro Costa, Caio Campos Ferreira, Lucas Pinto Bernar, Marcilene Paiva da Silva, Andréia de Andrade Mâncio, Marcelo Costa Santos, Sílvio Alex Pereira da Mota, Douglas Alberto Rocha de Castro, Sergio Duvoisin Junior, Luiz Eduardo Pizarro Borges, Marilena Emmi Araújo, Nélio Teixeira Machado   +12 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

On the relative asymptotic expressivity of inference frameworks [PDF]

Logical Methods in Computer Science
We consider logics with truth values in the unit interval $[0,1]$. Such logics are used to define queries and to define probability distributions.
Vera Koponen, Felix Weitkämper
doaj   +1 more source

The F-BAR Protein CIP4 Inhibits Neurite Formation by Producing Lamellipodial Protrusions [PDF]

Current Biology, 2012
Neurite formation is a seminal event in the early development of neurons. However, little is known about the mechanisms by which neurons form neurites. F-BAR proteins function in sensing and inducing membrane curvature. Cdc42-interacting protein 4 (CIP4), a member of the F-BAR family, regulates endocytosis in a variety of cell types.
Saengsawang, Witchuda, Mitok, Kelly, Viesselmann, Chris, Pietila, Lauren, Lumbard, Derek C., Corey, Seth J., Dent, Erik W.   +6 more
openaire   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Normalized solutions for biharmonic Schrodinger equations with potential and general nonlinearity

Electronic Journal of Differential Equations
We study the existence and non-existence of normalized solutions to the  biharmonic equation $$ \Delta ^2u-\Delta u+V(x)u+\lambda u=f(u) \quad \text{in }\mathbb{R}^N. $$ where \(0\neq V(x)\leq V_{\infty }:=\lim_{|x|\to \infty }V(x)\in (-\infty ,+\infty ]
Fengwei Zou, Shuai Yao, Juntao Sun
doaj   +1 more source

The F-BAR Protein Rapostlin Regulates Dendritic Spine Formation in Hippocampal Neurons [PDF]

Journal of Biological Chemistry, 2011
Pombe Cdc15 homology proteins, characterized by Fer/CIP4 homology Bin-Amphiphysin-Rvs/extended Fer/CIP4 homology (F-BAR/EFC) domains with membrane invaginating property, play critical roles in a variety of membrane reorganization processes. Among them, Rapostlin/formin-binding protein 17 (FBP17) has attracted increasing attention as a critical ...
Yohei, Wakita, Tetsuhiro, Kakimoto, Hironori, Katoh, Manabu, Negishi   +3 more
openaire   +2 more sources