Results 81 to 90 of about 12,080,229 (289)

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Non-homogeneous problem for fractional Laplacian involving critical Sobolev exponent

Electronic Journal of Differential Equations, 2017
In this article, we study the existence of positive solutions for the nonhomogeneous fractional equation involving critical Sobolev exponent $$\displaylines{ (-\Delta)^{s} u +\lambda u=u^p+\mu f(x), \quad u>0\quad \text{in } \Omega,\cr u =0, \quad \
Kun Cheng, Li Wang
doaj  

F-BAR Proteins of the Syndapin Family Shape the Plasma Membrane and Are Crucial for Neuromorphogenesis [PDF]

The Journal of Neuroscience, 2009
Coordinated functions of the actin cytoskeleton and microtubules, which require careful control in time and space, are indispensable for the drastic alterations of neuronal morphology during neuromorphogenesis and neuronal network formation. Actin filament formation driven by the Arp2/3 complex and its activator neural Wiskott-Aldrich syndrome protein (
Elavarasi, Dharmalingam, Akvile, Haeckel, Roser, Pinyol, Lukas, Schwintzer, Dennis, Koch, Michael Manfred, Kessels, Britta, Qualmann   +6 more
openaire   +2 more sources

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

The structure of 𝓐-free measures revisited

Advances in Nonlinear Analysis, 2020
We refine a recent result on the structure of measures satisfying a linear partial differential equation 𝓐μ = σ, μ, σ are Radon measures, considering the measure μ(x) = g(x)dx + μus(x̃)(μs(x̄) + dx̄) where x = (x̃,x̄) ∈ ℝk × ℝd−k, μus is a uniformly ...
Mitrovic D., Vujadinović Dj.
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Heavy-to-light scalar form factors from Muskhelishvili–Omnès dispersion relations

European Physical Journal C: Particles and Fields, 2018
By solving the Muskhelishvili–Omnès integral equations, the scalar form factors of the semileptonic heavy meson decays $$D\rightarrow \pi \bar{\ell }\nu _\ell $$ D→πℓ¯νℓ , $$D\rightarrow {\bar{K}} \bar{\ell }\nu _\ell $$ D→K¯ℓ¯νℓ , $${\bar{B}}\rightarrow
D. -L. Yao, P. Fernandez-Soler, M. Albaladejo, F. -K. Guo, J. Nieves   +4 more
doaj   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Microwave Kinetic Inductance Detector Made of Molecular Beam Epitaxy (MBE)-Grown MgB2 Film

Nanomaterials
We present a MgB2-based Microwave Kinetic Inductance Detector (MKID) featuring a quality factor Qi ~ 105 and noise equivalent power NEP ~ 10−14 W/Hz at 2 K.
Ariel Roitman, Corentin Pfaff, Thomas Hauet, Avner Shaulov, Yosef Yeshurun   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source