Results 121 to 130 of about 216,912 (262)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Glivenko-Cantelli for $f$-divergence
26 pages, 1 ...
Wang, Haoming, Lim, Lek-Heng
openaire +2 more sources
Quantum Rényi and f-Divergences from Integral Representations
Communications in Mathematical PhysicsSmooth Csiszár $f$-divergences can be expressed as integrals over so-called hockey stick divergences. This motivates a natural quantum generalization in terms of quantum Hockey stick divergences, which we explore here. Using this recipe, the Kullback-Leibler divergence generalises to the Umegaki relative entropy, in the integral form recently found by ...
Christoph Hirche, Marco Tomamichel
openaire +3 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
New Information Inequalities in Terms of Variational Distance and its Application
Journal of New Results in Science, 2016 In this work, new information inequalities are obtained and characterized on new generalized f- divergence (introduced by Jain and Saraswat (2012)) in terms of the Variational distance and these inequalities have been taken for evaluating some new ...
K. C. Jain, Praphull Chhabra
doaj
A Unifying Generator Loss Function for Generative Adversarial Networks
EntropyA unifying α-parametrized generator loss function is introduced for a dual-objective generative adversarial network (GAN) that uses a canonical (or classical) discriminator loss function such as the one in the original GAN (VanillaGAN) system.
Justin Veiner +2 more
doaj +1 more source
Stochastic Neighbor Embedding under f-divergences
, 2018 The t-distributed Stochastic Neighbor Embedding (t-SNE) is a powerful and popular method for visualizing high-dimensional data. It minimizes the Kullback-Leibler (KL) divergence between the original and embedded data distributions. In this work, we propose extending this method to other f-divergences.
Im, Daniel Jiwoong +2 more
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
New information inequalities on new generalized f-divergence and applications
Le Matematiche, 2015 In this work, we introduce new information inequalities on new generalized f-divergence in terms of well known Chi-square divergence. Further we obtain relations of other standard divergence as an application of new inequalities by using Logarithmic ...
K. C. Jain, Praphull Chhabra
doaj