Results 71 to 80 of about 25,362 (278)
Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report
Pediatric Blood &Cancer, EarlyView.ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan +6 more
wiley +1 more source
Generalizing the entanglement entropy of singular regions in conformal field theories
Journal of High Energy Physics, 2019 We study the structure of divergences and universal terms of the entanglement and Rényi entropies for singular regions. First, we show that for (3 + 1)-dimensional free conformal field theories (CFTs), entangling regions emanating from vertices give rise
Pablo Bueno +2 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu +8 more
wiley +1 more source
Scalable Hash-Based Estimation of Divergence Measures
, 2018 We propose a scalable divergence estimation method based on hashing. Consider two continuous random variables $X$ and $Y$ whose densities have bounded support.
Hero III, Alfred O., Noshad, Morteza
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song +15 more
wiley +1 more source
Relational $\star$-Liftings for Differential Privacy [PDF]
Logical Methods in Computer Science, 2019 Recent developments in formal verification have identified approximate liftings (also known as approximate couplings) as a clean, compositional abstraction for proving differential privacy. This construction can be defined in two styles.
Gilles Barthe +4 more
doaj +1 more source
Defining Roles in Pediatric Palliative Care: Perspectives From Oncology and Palliative Care Teams
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Early integration of pediatric palliative care (PPC) is associated with improved symptom management, quality of life, and healthcare utilization for children with cancer. Despite this, variation persists in how PPC is understood, operationalized, and integrated within pediatric oncology programs. In particular, ambiguity surrounding
Leeat Granek +13 more
wiley +1 more source
Entropic Regularization of Markov Decision Processes
Entropy, 2019 An optimal feedback controller for a given Markov decision process (MDP) can in principle be synthesized by value or policy iteration. However, if the system dynamics and the reward function are unknown, a learning agent must discover an optimal ...
Boris Belousov, Jan Peters
doaj +1 more source
Information Measures: the Curious Case of the Binary Alphabet
, 2014 Four problems related to information divergence measures defined on finite alphabets are considered. In three of the cases we consider, we illustrate a contrast which arises between the binary-alphabet and larger-alphabet settings.
Courtade, Thomas +4 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Blinatumomab is a bispecific T‐cell engager approved for the treatment of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). Outpatient home infusion reduces hospitalization burden and optimizes resource utilization, but is logistically challenging.
Angela Parra del Riego +10 more
wiley +1 more source