Results 131 to 140 of about 44,344 (261)

Induction of an anti-tumor immune response by TcdB-intoxicated B16-F10 cells.

, 2014
Mice were immunized once with PBS or 2×105 TcdB-exposed B16-F10 cells per mouse before challenge with lethal B16-F10 cells. Tumor volume (A) and the percentage of tumor-free mice (B) were measured.
Jufang Wang (91185), Gregorio Perez-Cordon (648696), Yuan Tian (225002), Haiying Wang (6869), Lianfa Shi (386158), Guangchao Li (648695), Hanping Feng (386160), Tuxiong Huang (648694), Li Mao (129512), Shan Li (110392), Xiaoning Wang (16150)   +10 more
core   +1 more source

Challenges and Coping Strategies of Migrant Parents in Türkiye: A Qualitative Study

Child &Family Social Work, EarlyView.
ABSTRACT This qualitative study explored the coping mechanisms used by 22 immigrant parents (nine men, 13 women) of Syrian, Iraqi, Afghan and Palestinian origin in Türkiye to cope with challenges related to food, shelter, healthcare and social exclusion while caring for their children.
Murat Altuntaş, Habibullah Akinci
wiley   +1 more source

Development of a Curcumin-Loaded Hyaluronic Acid Nanogel Formulation Using Wet Granulation Method for Enhanced Dissolution and Stability

Gels
Curcumin is widely recognized for its various pharmacological properties, including antioxidant, anti-inflammatory, and anti-tumor activities. Nevertheless, the development of curcumin as a therapeutic agent is impeded by its limited oral bioavailability,
Natkhanang Mookkie Boonpetcharat, May Thu Thu Kyaw, Veerakiet Boonkanokwong, Jittima Amie Luckanagul   +3 more
doaj   +1 more source

Mitigating the human link in emerging reptile fungal pathogen transmission

Conservation Biology, EarlyView.
Abstract Handling wild reptiles is common among amateur herpetology enthusiasts, professional researchers, social media influencers, and photographers. However, the potential for these interactions to spread diseases that threaten wild reptiles remains underappreciated.
Patrick S. Champagne, Richelle G. Butcher, Lachlan A. Bourke, Lorenzo Seneci, Laura F. Grogan   +4 more
wiley   +1 more source

Structural and functional insights into rhodopsin‐like and secretin‐like GPCR–arrestin interactions and regulation

The FEBS Journal, EarlyView.
Distinct GPCR phosphorylation barcodes and arrestin conformational states direct arrestin‐mediated signaling and trafficking. The graphical abstract depicts the structural diversity of GPCR–arrestin complexes by overlaying representative core‐engaged and tail‐engaged conformations.
Varsha Gupta, Annette G. Beck‐Sickinger   +1 more
wiley   +1 more source

Residency and Space Use of Endangered Smoothhound Sharks (Mustelus mustelus) in Relation to Marine Protection and Demersal Longline Fishing Along South Africa's South Coast

Fisheries Management and Ecology, EarlyView.
ABSTRACT Shark populations are declining globally and the effectiveness of marine protected areas (MPAs) as a conservation tool may vary by species and environmental context. This study assessed space use and residency of smoothhound sharks (Mustelus mustelus)—an endangered, yet highly exploited shark—in relation to spatial protection and fishing risk ...
Eugin Bornman, Taryn S. Murray, Neil Hammerschlag, Enrico Gennari   +3 more
wiley   +1 more source

Advanced Molecular Analysis in Hemophilia A in a Single Step: Next Generation Sequencing (NGS) and Copy Number Variation (CNV) Analysis

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Hemophilia A, an X‐linked bleeding disorder caused by pathogenic variants in the F8 gene, requires precise genetic diagnosis for optimal management. Conventional stepwise sequence and copy number variation (CNV) analyses are time‐consuming and may leave some cases unresolved.
Enise Avci Durmusalioglu, Esra Isik, Basak Durmus Ozen, Mehmet Mert Topaloglu, Nihal Karadas, Kaan Kavakli, Melike Sezgin Evim, Tolga Aslan, Erşen Kavak, Adalet Meral Gunes, Funda Tayfun Kupesiz, Alphan Kupesiz, Fahri Sahin, Tahir Atik   +13 more
wiley   +1 more source

Deep reinforcement learning for multi‐restart metaheuristics: an environment design for a hybrid of unbiased exploratory search and covariance matrix adaptation evolution strategy

International Transactions in Operational Research, EarlyView.
Abstract Multi‐restart metaheuristics can be highly effective for complex optimization problems, yet their performance depends critically on how restarts and algorithmic parameters are selected. This paper introduces a reinforcement learning approach for managing restart‐level decisions and parameter configurations in the UES–CMA‐ES hybrid ...
Antonio Bolufé‐Röhler, Bowen Xu
wiley   +1 more source

Navigating Alignment and Misalignment Across Linked Lives: Intergenerational Relationships in Three‐Generation Hong Kong Chinese Families

Journal of Marriage and Family, EarlyView.
ABSTRACT Objective Guided by life course and linked lives perspectives, this study examines how intergenerational relationships develop as patterns of solidarity, ambivalence, and conflict through negotiation across generational positions within three‐generation Hong Kong Chinese families.
Ke Ma, Rui Kang, Xue Bai
wiley   +1 more source

Celastrol inhibits mouse B16-F10 melanoma cell survival by regulating the PI3K/AKT/mTOR signaling pathway and repressing HIF-1α expression

Discover Oncology
Objective Melanoma, with its high degree of malignancy, stands as one of the most dangerous skin cancers and remains the primary cause of death from skin cancer.
Ping Zhao, Xing-Bo He, Xin-Yue Chen, Zhang-Long Li, Wen-Jia Xing, Wei Liu, Cong Ren, Xu-Dong Han, Bin Guo   +8 more
doaj   +1 more source