Results 171 to 180 of about 44,344 (261)

Fluorescent cAMP Analogs: Enzymatic Synthesis, Unexpected Photophysical Behavior and Protein Kinase A Recognition

open access: yesAngewandte Chemie, Volume 138, Issue 41, 5 October 2026.
Cyclic adenosine monophosphate (cAMP) is a key cellular second messenger. Adenylyl cyclase converts emissive isomorphic nucleoside triphosphates into fluorescent cAMPs. cthAMP displays unusually high brightness compared to thATP, its precursor, enabling real‐time monitoring of enzymatic reactions.
Deyuan Cong   +3 more
wiley   +2 more sources

Investigating Potential Adverse Drug Reactions of Lisdexamfetamine Using Sequence Symmetry Analysis

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.
ABSTRACT The prevalence of ADHD is increasing rapidly, and lisdexamfetamine is increasingly popular, but few studies investigate its safety. We performed a sequence symmetry analysis (SSA) using Danish register data to identify potential ADRs associated with lisdexamfetamine in 2013–2023.
Thomas Leth Jensen   +8 more
wiley   +1 more source

Extending reliability to intensive longitudinal data with the Kalman filter

open access: yesBritish Journal of Mathematical and Statistical Psychology, Volume 79, Issue 3, Page 493-512, November 2026.
Abstract Reliability is central to how researchers approach measurement in standard, group‐based analyses of single‐time‐point data, yet this critical aspect is often overlooked in the analysis of repeated observations. Since its inception, reliability has been a between‐person concept, but we redevelop this notion for within‐person designs by ...
Michael D. Hunter
wiley   +1 more source

Regulation of immune signal integration and memory by inflammation-induced chromosome conformation. [PDF]

open access: yesProc Natl Acad Sci U S A
Daniel B   +8 more
europepmc   +1 more source

Mapping of C5‐Blocking Monoclonal Antibodies Reveals New C5 Inhibitory Epitopes and Novel Modes of C5 Inhibition

open access: yesImmunology, Volume 179, Issue 3, Page 444-456, November 2026.
We identify four distinct C5 inhibitory epitopes, including two novel antibodies that selectively block membrane attack complex (MAC) assembly while preserving C5 cleavage and C5a generation. These findings establish selective MAC inhibition as a new therapeutic strategy for complement‐mediated diseases.
Rebekah Sian Cooke   +5 more
wiley   +1 more source

Mental disorders in childhood or adolescence and subsequent comprehensive school achievement

open access: yesJournal of Child Psychology and Psychiatry, Volume 67, Issue 11, Page 1796-1806, November 2026.
Background Childhood mental disorders are associated with poorer school achievement, with potential negative long‐term socio‐economic consequences, but few large‐scale studies have examined this association, particularly the role of age at onset.
Yan Li   +5 more
wiley   +1 more source

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