Results 231 to 240 of about 44,344 (261)

Novel Flavonoid Senotherapeutics Identified by Phenotypic Drug Discovery Reduce Senescence and Improve Multiple Markers of Healthspan

Aging Cell, Volume 25, Issue 10, October 2026.
Phenotypic screening and SAR‐guided drug design identified two flavonoid‐derived senolytics, SR29384 and SR31133, which selectively killed different types of senescent cells more efficiently and with greater selectivity than fisetin in culture. In aged and progeroid mice, these fisetin analogs reduced tissue senescence and improved physical function ...
Lei Justan Zhang, Rahagir Salekeen, Carolina Soto‐Palma, Qiuming Wu, Yuanjun He, Osama Elsallabi, Bilel Bdiri, Brian Hughes, Allancer Nunes, Wandi Xu, Borui Zhang, Abdalla Mohamed, Sara J. McGowan, Luise Angelini, Ryan O'Kelly, Theodore M. Kamenecka, Laura J. Niedernhofer, Paul D. Robbins   +17 more
wiley   +1 more source

Electroconvulsive Therapy and Time to Psychiatric Readmission in Schizophrenia

Acta Psychiatrica Scandinavica, Volume 154, Issue 4, Page 277-285, October 2026.
ABSTRACT Introduction There is evidence that electroconvulsive therapy (ECT) can augment the effects of antipsychotics in schizophrenia. However, there is limited evidence from Western populations on whether ECT reduces the risk of relapse compared to non‐ECT treatment in schizophrenia.
Linnea Stenmark, Mussie Msghina, Axel Nordenskjöld   +2 more
wiley   +1 more source

Prevalence and sociodemographic correlates of mental and behavioural disorders in Pakistan: findings from the first nationally representative cross-sectional survey. [PDF]

BMJ Public Health
Rahman RU, Sheehan DV, Javed A, Ahmed SH, Shafique K, Kanwal U, Afridi MI, Nizami AT, Rasool G, Taj R, Ansari MA, Naim M, Farooq S, Karim MS, Mehmood H, Ayub M, Memon A.   +16 more
europepmc   +1 more source

Blocking the m⁶Am methyltransferase PCIF1 releases STAT1-mediated Th1 immunity to potentiate cancer immunotherapy. [PDF]

Nat Commun
Huang J, Zhou J, Liu X, Liu X, Xiao Y, Li K, Ding C, Cai X, Mao W, Xu C, Kong Y, Deng Y, Song X, Yang M, Du D, Guo S, Chen K, Luo C, Yi C, Chen S, Li HB.   +20 more
europepmc   +1 more source

Effect of Formulation and Process Variables on the Stability and Quality Attributes of Digoxin Formulations. [PDF]

Pharmaceuticals (Basel)
Shaikh R, Dongala BP, Pansare SJ, Thota SK, Nutan MTH, Offili TU, Khan MA, Rahman Z.   +7 more
europepmc   +1 more source

Oocyte-inspired universal whole-cell vaccines against tumor heterogeneity. [PDF]

Proc Natl Acad Sci U S A
Guo S, Lei Q, Chen Y, Yang J, Lin J, Brinker CJ, Guo J, Zhu W.   +7 more
europepmc   +1 more source