Results 51 to 60 of about 246,623 (322)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Correct quantum chemistry in a minimal basis from effective Hamiltonians [PDF]

, 2015
We describe how to create ab-initio effective Hamiltonians that qualitatively describe correct chemistry even when used with a minimal basis. The Hamiltonians are obtained by folding correlation down from a large parent basis into a small, or minimal ...
Banerjee A., Bartlett R. J., Blaizot J.-P., Bondybey V., Brandow B. H., Casey S. M., Celani P., Dachsel H., Datta D., Dunning T. H., Durand P., Evangelista F. A., Evangelista F. A., Evangelista F. A. J., Freed K. F., Garnet Kin-Lic Chan, Głazek S. D., Hanauer M., Hilpert K., Huzinaga S., Iwata S., Karton A., Kedžuch S., Kemble E. C., Kendall R. A., Kurashige Y., Kutzelnigg W., Kutzelnigg W., Kutzelnigg W., Lyakh D. I., Mazziotti D. A., Mazziotti D. A., Mazziotti D. A., Mazziotti D. A., Nakano H., Neuscamman E., Neuscamman E., Neuscamman E., Onida G., Polyansky O. L., Potts D. M., Roos B. O., Roos B. O., Roos B. O., Shamasundar K., Sharma S., Stanton J. F., Stück D., Su C.-X., Tajti A., Ten-No S., Thomas J. Watson, Valeev E. F., Wegner F., Werner P., Westhaus P., White S. R., Yanai T., Yanai T., Yanai T., Yanai T., Yang J.   +61 more
core   +2 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Global value chains before and in times of the COVID-19 pandemic

International Journal of Management and Economics
This paper aims to examine the changes in global value chains (GVCs) in the years 2020–2022 (times of the COVID-19 pandemic) compared to 2019 (last year before the pandemic). GVCs are illustrated by diagrams based on the statistics on international trade
Folfas Paweł
doaj   +1 more source

Treatment seeking for alcohol-related issues during the COVID-19 pandemic: An analysis of an addiction-specialized psychiatric treatment facility

Heliyon, 2022
The COVID-19 pandemic and its societal impact may cause long-term behavioral changes in alcohol use due to increased psychological distress, unemployment, and time spent home.
Mitchell J. Andersson, Anders Håkansson
doaj   +1 more source

Instantons and odd Khovanov homology [PDF]

, 2014
We construct a spectral sequence from the reduced odd Khovanov homology of a link converging to the framed instanton homology of the double cover branched over the link, with orientation reversed.
Scaduto, Christopher W.
core   +2 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

A Potentially Fatal Outcome of Oral Contraceptive Therapy: Estrogen-Triggered Hereditary Angioedema in an Adolescent

JCRPE, 2023
Hereditary angioedema (HAE) is characterized by recurrent angioedema attacks with no urticaria. This disease has a high mortality due to asphyxia. Level of complement component 4 (C4), C1 esterase inhibitor (C1-INH) level and function, and genetic ...
Demet Demirkol, Gül Yeşiltepe Mutlu, Esra Birben, Özge Soyer, Özlem Yılmaz, Cansın Saçkesen   +5 more
doaj   +1 more source