Results 131 to 140 of about 142,938 (289)

DualPG‐DTA: A Large Language Model‐Powered Graph Neural Network Framework for Enhanced Drug‐Target Affinity Prediction and Discovery of Novel CDK9 Inhibitors Exhibiting in Vivo Anti‐Leukemia Activity

Advanced Science, EarlyView.
This study introduces DualPG‐DTA, a framework integrating two pre‐trained models to generate molecular and protein representations. It constructs dual graphs processed by specialized neural networks with dynamic attention for feature fusion, achieving superior benchmark performance.
Yihao Chen, Jindi Huang, Cong Liu, Shipeng Zhang, Xinze Li, Zhang Zhang, Tie‐Gen Chen, Ling Wang   +7 more
wiley   +1 more source

CELLama: Foundation Model for Single Cell and Spatial Transcriptomics by Cell Embedding Leveraging Language Model Abilities

Advanced Science, EarlyView.
CELLama is created, a framework that harnesses language models to convert cellular data into “sentences” that represent gene expression and metadata, enabling a universal embedding of cells. Unlike most single‐cell foundation models, CELLama supports scalable analysis and offers flexible applications including spatial transcriptomics.
Jeongbin Park, Sumin Kim, Jiwon Kim, Dongjoo Lee, Sungwoo Bae, Haenara Shin, Daeseung Lee, Hongyoon Choi   +7 more
wiley   +1 more source

F1-score of models under different numbers of triples.

Zhihao Zong (21680885), Hongtao Shan (17069603), Gaoyu Zhang (13039090), George Xianzhi Yuan (21680888), Shuyi Zhang (34553)   +4 more
openalex   +1 more source

Comparison of F1 Score Metrics for the Five Algorithms.

Ming Gao (115719), Mengshi Li (21464625), Zhi Ling (18928281), Jinhao Zhong (21464628), Han Ding (831540), Qinghua Wu (79148)   +5 more
openalex   +2 more sources

Keeping Pathologists in the Loop and an Adaptive F1-Score Threshold Method for Mitosis Detection in Canine Perivascular Wall Tumours. [PDF]

Cancers (Basel)
Rai T, Morisi A, Bacci B, Bacon NJ, Dark MJ, Aboellail T, Thomas SA, La Ragione RM, Wells K.   +8 more
europepmc   +1 more source

Random Forest classification macro-averaged F1-scores.

Alina Troglio (13165866), Peter Konradi (22319816), Andrea Fiebig (17625173), Ariadna Pérez Garriga (22319819), Rainer Röhrig (12313276), James Dunham (22319822), Ekaterina Kutafina (13165863), Barbara Namer (3106536)   +7 more
openalex   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Accuracy and F1-score comparison among six advanced models.

Hongwei Bai (1447999), Weiyan Tong (22032834), Zhenkun Geng (22032837), Cheng Gao (463618)   +3 more
openalex   +1 more source

Behavior‐ and Cell Type‐Specific Cortico‐Striatal Decoupling in a Parkinson's Disease‐Like Mouse Model

Advanced Science, EarlyView.
Utilizing dual‐site fiber photometry, this study examines cortico‐striatal coupling with cell type resolution, identifying behavior‐ and cell type‐specific cortico striatal decoupling and its dopamine‐dependent mechanism in a Parkinson's disease mouse model.
Xu‐Ran Yao, Yang Liu, Wei‐Tong Zheng, Mao‐Qing Huang, Kai‐Wen He   +4 more
wiley   +1 more source

Early detection of air leakage in IoT-connected compressors using enhanced data sampling with deep learning. [PDF]

Sci Rep
Lee GH, Kim J, Yoo YS, Lee IW.
europepmc   +1 more source