Results 171 to 180 of about 72,518 (220)

Comparison of ternary crystal complexes of F31 variants of human dihydrofolate reductase with NADPH and a classical antitumor furopyrimidine.

open access: closedAnti-cancer drug design, 1998
The novel furopyrimidine, N-[4-[(2,4-diaminofuro[2,3-d]pyrimidin-5-yl)-methyl]-methylamino] -benzoyl]-L-glutamate (MTXO), a classical antifolate with weak antitumor activity compared with methotrexate (MTX), has been studied as inhibitorcofactor ternary crystal complexes with recombinant Phe-31 to Ser (F31S) and Phe-31 to Gly (F31G) variant human ...
Vivian Cody   +5 more
semanticscholar   +5 more sources

Enniatins of Fusarium sp. Strain F31 and Their Inhibition of Botrytis cinerea Spore Germination

open access: closedJournal of Natural Products, 2004
A spectrum of enniatins was isolated from Fusarium sp. strain F31 by bioassay-guided isolation directed against Botrytis cinerea. Two new enniatins, J(2) (7) and J(3) (8), were co-isolated and both contained, in addition to three hydroxyisovaleric acid units, N-methylated l-alanine, l-valine, and l-isoleucine units, differing only in their primary ...
Anton Pohanka   +5 more
semanticscholar   +4 more sources

Manische Episode (F30) und bipolare affektive Störung (F31)

open access: closed, 2009
Die klinischen Kriterien der ICD-10 definieren die manische Episode (F30) durch eine gehobene oder gereizte Stimmung und eine deutliche Antriebssteigerung. Folgende Subtypen sind zu unterscheiden: Hypomanie (F30.0) Manie (F30.1) sowie Manie mit synthymen (F30.20) oder parathymen (F30.21) psychotischen Symptomen (F30.2).
S. Rothenhöfer   +2 more
semanticscholar   +4 more sources
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A Ganoderma lucidum polysaccharide F31 alleviates hyperglycemia through kidney protection and adipocyte apoptosis

International Journal of Biological Macromolecules, 2023
In this paper, we reported an excellent hypoglycemic effect of a Ganoderma lucidium polysaccharide F31 with efficacies between 45 and 54 %, approaching to that of liraglutide (52 %). Significantly, F31 reduced the body weight gains and food intakes. F31 decreased 4 key compounds, consisting of adenosine, adenosine, galactitol and glycerophosphocholine ...
Jiaqi, Jiao   +13 more
openaire   +3 more sources

F31 Understanding cognitive heterogeneity beyond disease burden in huntington’s disease [PDF]

open access: possibleClinical studies, 2018
Background Despite its monogenic cause, the cognitive problems in Huntington’s Disease are heterogeneous. This is particularly pronounced in the premanifest (preHD) stage of the disease. The existing tools cannot explain all of the heterogeneity observed nor can they accurately inform the progression of these aspects of the disease at an individual ...
Wei-Li Kuan   +3 more
openaire   +2 more sources

Writing a Competitive Individual National Research Service Award (F31) Application

Western Journal of Nursing Research, 2013
The National Institutes of Health (NIH) are committed to increasing the number of PhD-prepared persons to meet the demand for well-trained behavioral, biological, and biobehavioral scientists. The Ruth L. Kirschstein National Research Service Award (NRSA) individual Predoctoral Fellowship (F31) program provides financial support for full-time PhD ...
S. Rawl
openaire   +4 more sources

Antidiabetic activity of Ganoderma lucidum polysaccharides F31 down-regulated hepatic glucose regulatory enzymes in diabetic mice

Journal of Ethnopharmacology, 2017
Ganoderma lucidum (Lin Zhi) has been used to treat diabetes in Chinese folk for centuries. Our laboratory previously demonstrated that Ganoderma lucidum polysaccharides (GLPs) had hypoglycemic effects in diabetic mice. Our aim was to identify the main bioactives in GLPs and corresponding mechanism of action.Four polysaccharide-enriched fraction were ...
Jumei Zhang   +5 more
openaire   +4 more sources

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