Results 101 to 110 of about 185,022 (244)

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Toniná : Groupe F4 avant fouilles

, 1979
Toniná, municipio Ocosingo, ChiapasGroupe F4 avant fouille et après ...
Letterlé, Frédéric
core  

Organic Nanozyme‐Embedded Biotherapeutic Thermosensitive Hydrogel for Extracellular GSH Depletion and Postoperative Tumor Suppression

Advanced Science, EarlyView.
A temperature‐sensitive hydrogel loaded with cyanine nanozymes and Escherichia coli is locally injected into postoperative tumor resection beds. Upon light irradiation, synergistic PTT and PDT work with cascaded reactive oxygen species to deplete extracellular GSH, eliminate residual tumor cells, and induce robust antitumor immune responses for ...
Cong Jiang, Zifan Yang, Rong Guo, Meng Suo, Guowei Wang, Dong Chen, Lilin Su, Fuhuan Wang, Shipeng Ning, Kelong Fan, Xuan Wang   +10 more
wiley   +1 more source

A Preliminary Investigation of the Association of Sleep With Inflammation and Oxidative Stress Biomarkers and Functional Outcomes After Stroke Rehabilitation

Scientific Reports, 2017
This study examined the association of sleep with inflammation and oxidative stress biomarkers, and with functional outcomes, after stroke rehabilitation. The rehabilitation effects on biomarkers and functional outcomes were also evaluated.
Ting-ting Yeh, Yu-wei Hsieh, Ching-yi Wu, Jong-shyan Wang, Keh-chung Lin, Chia-ling Chen   +5 more
doaj   +1 more source

F4 receptor-independent priming of the systemic immune system of pigs by low oral doses of F4 fimbriae

, 2002
Oral administration of F4 fimbriae of Escherichia coli induces intestinal mucosal immune responses in F4 receptor-positive (F4R(+)) pigs, but trot in F4R(-) pigs. We examined whether F4 fimbriae in F4R(-) animals behave like a food antigen and can induce
Cox, E., Goddeeris, Bruno, Van den Broeck, W., Bouchaut, H.   +3 more
core   +1 more source

Inorganic Nanomaterials can Promote or Inhibit Tumor Metastasis Depending on Tumor Microenvironment Composition

Advanced Science, EarlyView.
As engineered nanomaterials gain prominence in cancer imaging and therapy, understanding their impact on tumor progression becomes increasingly critical. We demonstrate that gold and silica‐coated gold nanomaterials can either suppress or enhance breast cancer metastasis through distinct tumor microenvironment interactions, while identifying ...
Kiana Buttiens, Xiaoqi Zheng, Xueqi Fan, Mukaddes Izci, Christy Maksoudian, Irati Perez Gilabert, Tianjiao Chu, Filipa Goncalves, Jonas Dehairs, Johan Swinnen, Bella B. Manshian, Stefaan J. Soenen   +11 more
wiley   +1 more source

Trade and biodiversity conservation in Africa: Complementary roles of environmental provisions in preferential trade agreements and property rights

Cleaner and Responsible Consumption
Biodiversity loss has become a major environmental concern in regions experiencing rapid trade integration, yet the roles of trade agreements and property rights in shaping biodiversity outcomes remains insufficiently understood.
Michael Tutu Boadu, Camara K. Obeng
doaj   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

Mucin 4 polymorphism, F4 binding to villi and brush border membrane proteins and F4 immunisation can differentiate pigs as tools towards identifying F4R

, 2011
F4+ enterotoxigenic Escherichia coli (ETEC) are an important cause of diarrhoea and mortality in piglets. Currently, there is no reliable genetic test to screen for F4 receptor (F4R) negative pigs (F4+ ETEC resistant).
Coddens, AnneliesDI04001997453201801001717866FA02BE32-F0ED-11E1-A9DE-61C894A0A6B4, Nguyen Van, Ut, Goetstouwers, TiphanieUGent0000602609458020007042949779601716240208E5AC-F0EE-11E1-A9DE-61C894A0A6B4, Van Poucke, Mario, Coddens, Annelies, Peelman, Luc, Peelman, LucDI078010007212910000-0003-3853-5310F469A738-F0ED-11E1-A9DE-61C894A0A6B4, Goetstouwers, Tiphanie, Melkebeek, VesnaUGent001997122084801001663811979254812436FAC2D870-F0ED-11E1-A9DE-61C894A0A6B4, Cox, EricDI048010006694580000-0003-4281-2990F4500670-F0ED-11E1-A9DE-61C894A0A6B4, Melkebeek, Vesna, Nguyen Van, UtUGent0000808582878020007051069770759282130000-0002-3354-6419153A6DF8-F0EE-11E1-A9DE-61C894A0A6B4, Cox, Eric, Van Poucke, MarioDI078010009940060000-0002-4316-8984F4DDD658-F0ED-11E1-A9DE-61C894A0A6B4   +13 more
core