Results 111 to 120 of about 185,022 (244)

Conserved regions in the sequence of the F4 (K88) fimbrial adhesin FaeG suggest a donor strand mechanism in F4 assembly

, 2004
Oral immunization of newly weaned piglets with recombinant F4 (K88) fimbrial adhesin FaeG induces a F4-specific immune response, significantly reducing F4(+) Escherichia coli excretion following challenge. In order to use FaeG subunits in an Oral vaccine
Joensuu, J., Cox, E., Goddeeris, Bruno, Cox, Eric, Imberechts, H., Imberechts, H, Schepers, E., Verdonck, Frank, Verdonck, F., Schepers, Eva, Joensuu, J   +10 more
core   +1 more source

Autophagy Orchestrates Anti‐Tumor Immunity to Enhance Chemosensitivity via the FBXW2/C/EBPβ/TIMP‐2 Axis in Colorectal Cancer

Advanced Science, EarlyView.
Chemotherapy leverages tumor‐cell autophagy to reshape the colorectal cancer immune microenvironment. Autophagy degrades FBXW2 to promote C/EBPβ‐mediated TIMP‐2 transcription and MMP‐9 suppression, driving intra‐tumoral CD8+ T‐cell infiltration. Targeting MMP‐2/9 or restoring TIMP‐2 overcomes chemo‐resistance in autophagy‐deficient tumors. ABSTRACT The
Bing Cheng, Chaoying Wei, Zhitong Niu, Jinxin Chen, Guojie Long, Yingzhen Weng, Qiufeng Liu, Yue Jiang, Panpan Wang, Ronghua Zhang, Qiang Yu, Xiaojian Wu, Wenyu Wang   +12 more
wiley   +1 more source

Tonina : Structure F4-4 T56

, 1979
Tonina, Municipio Ocosingo, ChiapasOp III. Zone Nord structure F4-4.T56.
Arnauld, Marie-Charlotte, Toniná, Projet   +1 more
core   +1 more source

CD11c⁺ F4/80

, 2013
− cells are the most potent antigen-presenting cells in lungs of mycoplasma-infected mice. CD11c− F4/80+ (F4/80+), CD11c+ F4/80− (CD11c+), and CD11c− F4/80− (Neg) cells were isolated from lungs of infected and control (broth-inoculated) mice to be used ...
Xiangle Sun (285335), Harlan P. Jones (285336), Nicole Dobbs (285337), Sheetal Bodhankar (285338), Jerry W. Simecka (230477)   +4 more
core   +1 more source

CHST1 Drives Immunotherapy Resistance in Triple‐Negative Breast Cancer by Orchestrating an Immunosuppressive Microenvironment via the NKRF–CCL20–Macrophage Axis

Advanced Science, EarlyView.
Proposed model of CHST1‐associated immune remodeling in triple‐negative breast cancer. In CHST1‐low tumors, greater nuclear accumulation of NKRF is associated with repression of an NF‐κB‐related CCL20 transcriptional program and an immune‐inflamed microenvironment.
Shu‐Hao Jiang, Xiao‐Han Ying, Ruo‐Qing Wang, Qun Zhang, Li Chen, Zhi‐Ming Shao, Jun‐Jie Li   +6 more
wiley   +1 more source

CONNECTIVE TISSUE GROWTH FACTOR ASSESSMENT: DETERMINATION OF CUT-OFF POINTS FOR LIVER FIBROSIS IN CHOLESTASIS

Annals of Hepatology
Introduction and Objectives: Connective Tissue Growth Factor (CTFG) is a multifunctional protein, plays a crucial role as a mediator in fibrogenic pathways involved in the development of liver disease.
Jessica Mejía Ramírez, Fatima Higuera de la Tijera, Carolina Guzman, Ángel Daniel Santana Vargas, Viridiana López Ladron de Guevara, Cristian Yamin Sánchez Sánchez, Diego Fernando Abendaño Rivera, Maria Argentina Díaz Castro, Kevin Vázquez Hernández, Karla Marysol Meixueiro Olivera, Jose Luis Pérez Hernández   +10 more
doaj   +1 more source

Macrophage PABPC4‐SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer

Advanced Science, EarlyView.
In the CRC microenvironment, macrophage PABPC4 binds to the 3′UTR of SPP1 mRNA to stabilize its expression, thereby sustaining M2‐like immunosuppressive macrophage polarization. Concurrently, this axis suppresses CD8+ T cell effector functions via CD44 signaling, collectively fostering an immunosuppressive niche that drives tumor progression.
Meng Wang, Fang Yang, Yuan Gao, Liuli Li, Yulan Huang, Hui Yao, Sijie Zhao, Kun Zhao, Tianying Zhang, Hui Heng, Jiaxin Xu, Yuancai Xiang, Weidong Xiao, Shaofan Hu, Hongming Miao   +14 more
wiley   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Glycosylated F4 (K88) fimbrial adhesin FaeG expressed in barley endosperm induces ETEC-neutralizing antibodies in mice

, 2006
The F4-positive enterotoxigenic Escherichia coli (ETEC) strains are a frequent cause of porcine post-weaning diarrhea. Orally administered F4 fimbriae or FaeG, the major subunit and adhesin of F4, induce a protective mucosal immune response in F4 ...
Nuutila, Anna-Maria, Oksman-Caldentey, Kirsi-Marja; id_orcid, Teeri, Teemu, Joensuu, Jussi, Kotiaho, Mirkka, Valmu, Leena, Niklander-Teeri, Viola   +6 more
core   +1 more source

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

Advanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen, Wenyi Lin, Lang Jiang, Xuehui Gao, Chenyan Yu, Jili Han, Zhenping Liu, Xuefeng Li, Mei He, Chang Li, Qilan Li, Chaoying Song, Jiqian Xu, You Shang   +13 more
wiley   +1 more source