Results 231 to 240 of about 72,617 (250)

Selective modulation of NaV channel gating counteracts aberrant hyperexcitability and rescues motor function and survival in a model of spinal muscular atrophy

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 23, Page 6824-6846, December 2026.
Background and Purpose Spinal muscular atrophy (SMA) is a motor neuron disease caused by SMN1 gene loss, leading to reduced survival motor neuron (SMN) protein and progressive motor neuron degeneration. Although SMN‐restoring therapies improve outcomes, residual disease burden and non‐curative efficacy underscore the need for complementary treatments ...
Fernanda C. Cardoso   +3 more
wiley   +1 more source

Integration of hereditary thrombophilia data and polygenic risk scores into prognostic models improves differential diagnosis of CTEPH. [PDF]

open access: yesFront Cardiovasc Med
Kubkin Y   +12 more
europepmc   +1 more source

Young Learners' Motivation for AI‐Supported Extracurricular French Vocabulary Learning: A Q Methodological Study

open access: yesEuropean Journal of Education, Volume 61, Issue 4, December 2026.
ABSTRACT Artificial intelligence (AI) is increasingly reshaping extracurricular language learning, yet little is known about how young learners construct motivation when using AI to learn less commonly taught foreign languages. This study investigates primary school students' motivational typologies and the factors related to these configurations in AI‐
Xun Lu, Nanlan Pei
wiley   +1 more source

Advanced Molecular Analysis in Hemophilia A in a Single Step: Next Generation Sequencing (NGS) and Copy Number Variation (CNV) Analysis

open access: yesInternational Journal of Laboratory Hematology, Volume 48, Issue 6, Page 1445-1454, December 2026.
ABSTRACT Background Hemophilia A, an X‐linked bleeding disorder caused by pathogenic variants in the F8 gene, requires precise genetic diagnosis for optimal management. Conventional stepwise sequence and copy number variation (CNV) analyses are time‐consuming and may leave some cases unresolved.
Enise Avci Durmusalioglu   +13 more
wiley   +1 more source

Characterisation of seminal plasma-derived mediators involved in PMN evasion of ram spermatozoa <i>in vitro</i>. [PDF]

open access: yesFront Immunol
Warr S   +6 more
europepmc   +1 more source

Genetically Encoded Pentafluorophenylalanine Enables Quantitative Probing of Local Protein Malleability by 19F NMR. [PDF]

open access: yesJ Am Chem Soc
Paul N   +13 more
europepmc   +1 more source

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