Results 71 to 80 of about 8,318 (194)

Computational Insights into the Structural Basis for Reduced Hepatotoxicity of Novel Nonopioid Analgesics

ChemMedChem, Volume 20, Issue 22, November 18, 2025.
Docking and molecular dynamics simulations within CYP2E1 clarify the structural basis for the reduced hepatotoxicity of novel non‐opioid analgesics developed as safer alternatives to acetaminophen. The results reveal that hydrophobicity and substituent size critically influence binding conformations, thereby modulating toxicity.
Claire Coderch, Hernan A. Bazán, Nicolas G. Bazan, Bhattacharjee Surjyadipta, Julio Alvarez‐Builla, Beatriz de Pascual‐Teresa   +5 more
wiley   +1 more source

Cracking Risk and Overall Stability Analysis of Xulong High Arch Dam: A Case Study

Applied Sciences, 2018
It is of great significance to study the cracking risk, the overall stability, and the reinforcement measures of arch dams for ensuring long-term safety. In this study, the cracking types and factors of arch dams are summarized.
Peng Lin, Pengcheng Wei, Weihao Wang, Hongfei Huang   +3 more
doaj   +1 more source

Contributions to the faunistics of Odonata in Thailand [PDF]

, 2009
Distribution and habitat information are provided for 1578 adult specimens of Odonata representing 127 species in 70 genera and 16 families that were collected from 143 locations throughout Thailand. Of the species collected, 25 (20%) were represented by
Ferro, Michael L., Sites, Robert W., Vitheepradit, Akekawat   +2 more
core   +1 more source

Influence of Healthy Plant‐Based Fat Substitutes on the Sensory and Nutritional Properties of Oat‐Date Balls

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
Schematic overview of the formulation of oat–date balls enriched with peanut, coconut, and sesame butters and the subsequent evaluation of their antioxidant activity, total phenolic and flavonoid contents, proximate composition, texture, fatty acid profile, and sensory attributes.
Nashwa M. Younes, Mahmoud Younis, Mahmoud Khalil, Diaeldin Omer Abdelkarim, Samar M. S. Shawir   +4 more
wiley   +1 more source

Grass silage contaminated with Mycobacterium avium subspecies paratuberculosis (MAP): a possible source of paratuberculosis infection in ruminants?

Veterinární Medicína, 2010
Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of paratuberculosis (Johne's disease) in ruminants. Paratuberculosis can cause severe economic losses and is acknowledged as one of the most important diseases of ruminants today ...
J.L. Khol, V. Beran, P. Kralik, M. Trckova, I. Pavlik, W. Baumgartner   +5 more
doaj   +1 more source

Validation and standardization of IS900 and F57 real-time quantitative PCR assays for the specific detection and quantification ofMycobacterium aviumsubsp.paratuberculosis [PDF]

Canadian Journal of Microbiology, 2011
Mycobacterium avium subsp. paratuberculosis (Map) is the causative agent of Johne’s disease and may contribute to the onset and development of Crohn’s disease in humans. Rapid detection of Map is fundamental because of its reported isolation from pasteurized milk and its potential for transmission through environmental sources.
SIDOTI, Francesca, BANCHE, Giuliana, Astegiano S, ALLIZOND, VALERIA, CUFFINI, Annamaria, BERGALLO, Massimiliano   +5 more
openaire   +3 more sources

Amyloid Forming Human Lysozyme Intermediates are Stabilized by Non‐Native Amide‐π Interactions

Advanced Science, Volume 12, Issue 34, September 11, 2025.
Mutational variants of human lysozyme cause fatal systemic amyloidosis by depositing kilograms of protein in the viscera of patients. Central to this process is a partially unfolded protein intermediate state that initiates aggregation into amyloid fibrils.
Minkoo Ahn, Julian O. Streit, Christopher A. Waudby, Tomasz Włodarski, Angelo Miguel Figueiredo, John Christodoulou, Janet R. Kumita   +6 more
wiley   +1 more source

Optimization of IL-1RA structure to achieve a smaller protein with a higher affinity to its receptor

Scientific Reports, 2022
Interleukine-1 family cytokines are key orchestrators of innate and adaptive immunity. In particular, up-regulation of IL-1R1 via its agonistic ligands consisting of IL-1β and IL-1α is implicated in a variety of human diseases, such as rheumatoid ...
Mahsa Nouri Barkestani, Sina Naserian, Fatemeh Khoddam, Sara Shamdani, Bijan Bambai   +4 more
doaj   +1 more source

Dragging developers towards the core: How the free/libre/open source software community enhances developers' contribution [PDF]

, 2006
The paper presents a dynamic perspective on the landscape of Free/Libre/Open Source Software (FLOSS) developers' motivations and tries to isolate mechanisms sustaining developers' contribution over time.
Rullani, Francesco
core  

Predicting Forage Nutritional Quality With Near‐Infrared Spectroscopy

Journal of Sustainable Agriculture and Environment, Volume 4, Issue 3, September 2025.
ABSTRACT The quality of green forage is crucial in pasture grazing, influencing both animal welfare, environmental sustainability, and production yield. Traditionally, the evaluation of forage composition requires time‐consuming and costly chemical analysis. In this context, near‐infrared spectroscopy (NIR) emerges as a promising alternative.
Alessandro Benelli, Riccardo Primi, Chiara Evangelista, Raffaello Spina, Marco Milanesi, Daniele Pietrucci, Bruno Ronchi, Umberto Bernabucci, Roberto Moscetti   +8 more
wiley   +1 more source