Results 31 to 40 of about 1,233 (158)

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Overcoming the Catalytic Bucket Effect in Pt‐based High‐Entropy Nanocages Through Interface Defect and Strain Engineering

Advanced Science, EarlyView.
PtPdNiCuMnAu HENCs exhibit a remarkable half‐wave potential (E1/2) of 0.925 V vs. RHE. The catalyst displays exceptional electrochemical stability, with only a 4 mV negative shift in E1/2 and a mere 5.6% loss in MA after 10, 000 accelerated durability test cycles.
Qian Liu, Haoran Kang, Yiou Liu, Xiaowei Zhang, Xu Chen, Faming Gao   +5 more
wiley   +1 more source

Immunochemistry of human Lp[a]: characterization of monoclonal antibodies that cross-react strongly with plasminogen.

Journal of Lipid Research, 1991
Forty different monoclonal antibodies were produced from hybridomas that were raised against human Lp[a]. Of these, 14 strongly cross-reacted with plasminogen on ELISA screening assays while 16 clearly did not and 10 were only marginally cross-reactive ...
MA Lafferty, AM Salamon, DC Usher
doaj   +1 more source

Self‐Amplified Activatable Fluorescent Probe for Early Diagnosis of Acute Kidney Injury and High‐Throughput Screening of Natural Protectants

Advanced Science, EarlyView.
The PS‐QRC nanoprobe employs L‐serine as a targeting ligand for kidney injury molecule‐1 (KIM‐1) to achieve accumulation in injured renal tissues. Upon activation by reactive oxygen species (ROS), it undergoes a self‐amplifying cascade to release fluorophores for near‐infrared fluorescence (NIRF) imaging, enabling ultra‐early diagnosis of acute kidney ...
Yahui Chen, Meihong Liu, Mengchao Ding, Ye Liu, Chuanxu Zhu, Mingye Gong, Zhixuan Huang, Yi Zhang, Wei Xue, Youyong Yuan, Kewei Wang   +10 more
wiley   +1 more source

Income Inequality and Economic Complexity Nexus: The Moderating Roles of Institutional Quality and Globalization

Studia Universitatis Vasile Goldis Arad, Seria Stiinte Economice
This paper investigates the link between economic complexity and income inequality by addressing the moderating functions of institutional quality and globalization on economic complexity.
Erkişi Kemal
doaj   +1 more source

Expanded Farm Safety Net Payments Under the One Big Beautiful Bill Act

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT The One Big Beautiful Bill Act (OBBBA) strengthens the agricultural risk coverage (ARC) and price loss coverage (PLC) programs by aligning program parameters more closely with recent market dynamics and allows for an expansion in program acres. This study projects the increases in ARC‐County and PLC payments for corn, soybeans, and wheat under
Oranuch Wongpiyabovorn, Tayatorn Pongspikul, Alejandro Plastina, Anup Paudel, Chandan Bhattarai, Jennifer Ifft   +5 more
wiley   +1 more source

MolMiner: Toward Controllable, Three‐Dimensional‐Aware, Fragment‐Based Molecular Design

Advanced Intelligent Discovery, EarlyView.
MolMiner is a fragment‐based, geometry‐aware, and order‐agnostic generative model for molecular design with strong inductive biases. Using symmetry‐aware fragment assembly, dynamic three‐dimensional geometry, and multi‐property conditioning, MolMiner enables interpretable and controllable molecular generation.
Raul Ortega‐Ochoa, Tejs Vegge, Jes Frellsen   +2 more
wiley   +1 more source

Evaluation of F6 RILs for Drought Tolerance in Green Gram [Vigna radiata (L.)]

International Journal of Bio-Resource and Stress Management, 2023
An experiment was conducted at the experimental plot of College of Agriculture, Hassan, Karnataka, India during summer, i.e. January–April, 2018 with an objective to screen F6 RILs for drought tolerance using Augmented Randomized Block Design with 152 ...
M. S. P. Kanavi, G. Somu, N. Marappa, K. S. Shashidhara, N. Nagesh   +4 more
doaj   +1 more source

Re‐humanizing anatomy? Learning through human body donors in physiotherapy education

Anatomical Sciences Education, EarlyView.
Abstract Anatomical knowledge underpins clinical skills and professional identity in physiotherapy. However, dedicated teaching has declined in recent years. Body donor‐based learning, though common in medical education, is rarely used in physiotherapy.
Robert Parish, Chris Carter, John Stephens, Debs Patten   +3 more
wiley   +1 more source

Carbon nanostructures for high-frequency line-filtering supercapacitors

Frontiers in Nanotechnology
Supercapacitors (SCs) are considered one of the front-runner energy storage devices for future electronic and automobile device applications. Even though their high-power densities, fast charge/discharge, and long cycling stabilities make them promising ...
Neelakandan M. Santhosh, Uros Cvelbar
doaj   +1 more source