Results 161 to 170 of about 26,635,104 (298)

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source

The cosmological constant as an eigenvalue of f(R)-gravity Hamiltonian constraint

, 2007
In the framework of ADM formalism, it is possible to find out eigenvalues of the WDW equation with the meaning of vacuum states, i.e. cosmological constants, for f (R) theories of gravity, where f (R) is a generic analytic function of the Ricci ...
CAPOZZIELLO, SALVATORE, GARATTINI, Remo (ORCID:0000-0002-0747-401X), R. Garattini   +2 more
core  

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Dirac–Bergmann analysis and degrees of freedom of coincident f(Q)-gravity

European Physical Journal C: Particles and Fields
We investigate the propagating degrees of freedom of f(Q)-gravity in a 4-dimensional space-time under the imposition of the coincident gauge by performing the Dirac–Bergmann analysis.
Kyosuke Tomonari, Sebastian Bahamonde
doaj   +1 more source

Amphibious Movement of Microrobots Inspired by Water Spiders

Advanced Science, EarlyView.
Inspired by the water strider, a novel microrobot is designed to maintain amphibious mobility in complex environments. It retains the ability to traverse the air‐liquid interface and perform directional movement within sophisticated, multifaceted environments, including complex gastric wall structures, with precise controllability.
Xiao Hu, Run Ouyang, Zhuhao Shi, Wanqiong Tao, Zuchao Zhu, Peifeng Lin, Jianzhong Lin, Luca Brandt   +7 more
wiley   +1 more source

Periostin‐CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy

Advanced Science, EarlyView.
POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Tiantian Wu, Ruotong Li, Xiaoyue Zhang, Dandan Chen, Jianmeng Yang, Mengmeng Li, Yuhan Yin, Ya Wang, Yuqiu Tian, Haoling Yan, Dan Cui, Jiangping Song, Gaoliang Ouyang   +12 more
wiley   +1 more source

Bioinspired Metastable Transient Peeling for Repeatable Rapid Release

Advanced Science, EarlyView.
Inspired by the explosive seed ejection of the squirting cucumber, this work introduces metastable transient peeling that temporally regulates stored interfacial energy release via a tunable energy barrier. A viscoelastic hemispherical gripper achieves 52 ms ultrafast, residue‐free release with 300 000‐cycle durability, enabling damage‐free handling of
Lvzhou Li, Qingyue Li, Yao Hu, Xu Dong, Xiangli Wen, Kai Zhu, Yaoyao Jiang, Yu Tian, Jianning Ding   +8 more
wiley   +1 more source

f(R) gravity with spacetime torsion [PDF]

The duality between a higher curvature $f(R)$ gravity model and a scalar-tensor theory helps to bring out the role of the additional degree of freedom originating from the higher derivative terms in the gravity action.
Paul, Tanmoy, Kumar, Hitender, SenGupta, Soumitra   +2 more
core   +1 more source

Extension of the Schwarzschild black hole solution in f(R) gravitational theory and its physical properties

European Physical Journal C: Particles and Fields
The successes of f(R) gravitational theory as a logical extension of Einstein’s theory of general relativity (GR) encourage us to delve deep into this theory and continue our study to attempt to derive an extension of the Schwarzschild black hole (BH ...
G. G. L. Nashed
doaj   +1 more source

Gravitational waves in f (R,T) and f (R,Tφ) theories of gravity

, 2018
There is a host of alternative theories of gravitation in the literature, among them the f(R,T) and f(R,Tφ) theories recently elaborated by Harko et al. In these theories, R, T and Tφ are respectively the Ricci scalar and the traces of the energy-momentum tensors of matter and of a scalar field. There is already in the literature a series of studies of
Alves, M. E.S., Moraes, P. H.R.S., De Araujo, J. C.N., Malheiro, M.   +3 more
openaire   +2 more sources