Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
T HE E F F E CT O F USING DIR E CTE D R E AD ING T HINK IN G AC T IVIT Y (D RTA) S T RA T E G Y ON READ ING COM PREHE NSIO N AC HIE VEM E NT OF T HE T E NTH G RA DE S T UD E NTS AT S M AN AR J ASA JE M B E R IN TH E 201 2 /201 3 AC AD E M IC Y E AR [PDF]
, 2014 R e a ding in Eng li sh a s a F or e i g n L a n g u a g e (E F L ) c ontribut e s a pa rt of e ssential skil ls to be tau g ht be sides the other skil ls.
G ALUH E K A YU NIT A
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Oh, it's G—L—O—R—Y to know I'm F—R—E—E; [PDF]
, 1958 voiceCollected by Gladys McChristian For Mary C. Parler Transcribed by Frances Majors Sung by Gladys McChristian Huntsville, Arkansas July 16, 1958 Reel 246, Item 13 The Spelling Song Some folks jump up and down all night at a D-A-N-C-E; Then they go to ...
McChristian, Gladys
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
AN AL I S A K O M P AR ASI DA YA T RA NSM I S I GE L OMB AN G F M DA N GE L OM B AN G A M P AD A K E AD AA N 3 DI M E NSI [PDF]
, 2014 B e r da s a r ka n m e d i u m pe r a m ba t a nny a ge l o m ba n g t e r b a g i m e nj a d i dua j e nis y a i t u g e l o m ba n g m e ka ni k da n ge l o m ba
I RI NE NU R F I RM AY ASARI
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Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
T HE E F F E CT O F USING T HINK P AIR S H AR E T E CHNIQUE ON T HE E IG HT H G RA DE S T UD E NTS ’ R E AD I NG COM PREHE NSIO N A CHIE VEM E NT AT S M P N 3 B AN G S A L S AR I JEMBE R [PDF]
, 2014 Thin k-P a i rSh are t echni que i s o n e o f t h e t y pe s o f i n co o pera t i v e l ear ni ng t h at creat es a m o re act i ve pro ces s. This
DIY AH RENI F AU Z IY ATI
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Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source