Results 131 to 140 of about 2,152,852 (279)
Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang +12 morewiley +1 more sourceIMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd +9 morewiley +1 more sourceBURABILITY OF LAMINATEB RAILROAB TIES
Forestist, 1995 Pathological exam inations w hich included soil-block tests (test fungi: L entin ııs lep id eu s a n d G lo eo p lıyllu m tra b eu m ) w ere m ade on borings taken in 1976 from the upper surfaces o f 30 Iam inated crossties (upperm ost Iamination o f ...Haluk ÜNLİGİLdoaj +2 more sourcesEstablishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns +10 morewiley +1 more sourceDifferential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales +11 morewiley +1 more sourceCCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets +12 morewiley +1 more sourceKDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan +16 morewiley +1 more sourceThe CMS experiment at the CERN LHC
, 2008 S. Chatrchyan, G. Hmayakyan, V. Khachatryan, A. Sirunyan, W. Adam, T. Bauer, T. Bergauer, H. Bergauer, M. Dragicevic, J. Erö, M. Friedl, R. Frühwirth, V. Ghete, P. Glaser, C. Hartl, N. Hoermann, J. Hrubec, S. Hänsel, M. Jeitler, K. Kastner, M. Krammer, M. Markytan, I. Mikulec, B. Neuherz, Tobias Nöbauer, M. Oberegger, M. Padrta, M. Pernicka, P. Porth, H. Rohringer, S. Schmid, T. Schreiner, R. Stark, H. Steininger, J. Strauss, A. Taurok, D. Uhl, W. Waltenberger, G. Walzel, E. Widl, C. Wulz, V. Petrov, V. Prosolovich, V. Chekhovsky, O. Dvornikov, I. Emeliantchik, A. Litomin, V. Makarenko, I. Marfin, V. Mossolov, N. Shumeiko, A. Solin, R. Stefanovitch, S. Gonzalez, A. Tikhonov, A. Fedorov, M. Korzhik, O. Missevitch, R. Zuyeuski, W. Beaumont, M. Cardaci, E. D. Langhe, E. Wolf, E. Delmeire, S. Ochesanu, M. Tasevsky, P. Mechelen, J. D’Hondt, S. D. Weirdt, O. Devroede, R. Goorens, S. Hannaert, J. Heyninck, J. Maes, M. Mozer, S. Tavernier, W. Doninck, L. V. Lancker, P. Mulders, I. Villella, C. Wastiels, C. Yu, O. Bouhali, O. Charaf, B. Clerbaux, P. D. Harenne, G. Lentdecker, J. Dewulf, S. Elgammal, R. Gindroz, G. Hammad, T. Mahmoud, L. Neukermans, M. Pins, R. Pins, S. Rugovac, J. Stefanescu, V. Sundararajan, C. Velde, P. Vanlaer, J. Wickens, M. Tytgat, S. Assouak, J. Bonnet, G. Bruno, J. Caudron, B. D. Callatay, De Jeneret, S. Visscher, P. Demin, D. Favart, C. Felix, B. Florins, E. Forton, A. Giammanco, G. Grégoire, M. Jonckman, D. Kcira, T. Keutgen, V. Lemaitre, D. Michotte, O. Militaru, S. Ovyn, T. Pierzchala, K. Piotrzkowski, V. Roberfroid, X. Rouby, N. Schul, O. Aa, N. Beliy, E. Daubie, P. Herquet, G. Alves, M. Pol, M. Souza, M. Vaz, D. Damiao, V. Oguri, A. Santoro, A. Sznajder, E. Gregores, R. Iope, S. Novaes, T. Tomei, T. Anguelov, G. Antchev, I. Atanasov, J. Damgov, N. Darmenov, L. Dimitrov, V. Genchev, P. Iaydjiev, A. Marinov, S. Piperov, S. Stoykova, G. Sultanov, R. Trayanov, I. Vankov, C. Cheshkov, A. Dimitrov, M. Dyulendarova, I. Glushkov, V. Kozhuharov, L. Litov, M. Makariev, E. Marinova, S. Markov, M. Mateev, I. Nasteva, B. Pavlov, P. Petev, P. Petkov, V. Spassov, Z. Toteva, V. Velev, V. Verguilov, J. Bian, Guo-ming Chen, He-Sheng Chen, M. Chen, C. Jiang, B. Liu, X. Shen, H. Sun, J. Tao, Jian Wang, Mingming Yang, Zhiqin Zhang, W. Zhao, H. Zhuang, Y. Ban, J. Cai, Y. Ge, S. Liu, H. Liu, L. Liu, S. Qian, Q. Wang, Z. Xue, Zongchang Yang, Y. Ye, J. Ying, P. Li, J. Liao, Z. Xue, D. Yan, H. Yuan, C. Montoya, J. Sanabria, N. Godinovic, I. Puljak, I. Sorić, Z. Antunović, M. Dželalija, K. Marasovic, V. Brigljevic, K. Kadija, S. Morović, R. Fereos, C. Nicolaou, A. Papadakis, F. Ptochos, P. Razis, D. Tsiakkouri, Z. Zinonos, A. Hektor, M. Kadastik, K. Kannike, É. Lippmaa, M. Müntel, M. Raidal, L. Rebane, P. Aarnio, E. Anttila, K. Banzuzi, P. Bulteau, S. Czellár, N. Eiden, C. Eklund, P. Engstrom, A. Heikkinen, A. Honkanen, J. Härkönen, V. Karimäki, H. Katajisto, R. Kinnunen, J. Klem, J. Kortesmaa, M. Kotamäki, A. Kuronen, T. Lampén, K. Lassila-Perini, V. Lefébure, S. Lehti, T. Lindén, P. Luukka, S. Michal, F. Brígido, T. Mäenpää, T. Nyman, J. Nysten, E. Pietarinen, K. Skog, K. Tammi, E. Tuominen, J. Tuominiemi, D. Ungaro, T. Vanhala, L. Wendland, C. Williams, M. Iskanius, A. Korpela, G. Polese, T. Tuuva, G. Bassompierre, A. Bazan, P. David, J. Ditta, G. Drobychev, N. Fouque, J. Guillaud, V. Hermel, A. Karneyeu, T. L. Flour, S. Lieunard, M. Maire, P. Mendiburu, P. Nédélec, J. Peigneux, M. Schneegans, D. Sillou, J. Vialle, M. Anfreville, J. Bard, P. Besson, E. Bougamont, M. Boyer, P. Brédy, R. Chipaux, M. Dejardin, D. Denegri, J. Descamps, B. Fabbro, J. Faure, S. Ganjour, F. Gentit, A. Givernaud, P. Gras, G. H. Monchenault, P. Jarry, C. Jeanney, F. Kircher, M. Lemaire, Y. Lemoigne, B. Levésy, E. Locci, J. Lottin, I. Mandjavidze, M. Mur, J. Pansart, A. Payn, J. Rander, J. Reymond, J. Rolquin, F. Rondeaux, A. Rosowsky, J. Rousse, Z. Sun, J. Tartas, A. Lysebetten, P. Venault, P. Verrecchia, M. Anduze, J. Badier, S. Baffioni, M. Bercher, C. Bernet, U. Berthon, J. Bourotte, A. Busata, P. Busson, M. Cerutti, D. Chamont, C. Charlot, C. Collard, A. Debraine, D. Decotigny, L. Dobrzyński, O. Ferreira, Y. Geerebaert, J. Gilly, C. Gregory, L. Riveros, M. Haguenauer, A. Karar, B. Koblitz, D. Lecouturier, A. Mathieu, G. Milleret, P. Miné, P. Paganini, P. Poilleux, N. Pukhaeva, N. Regnault, T. Romanteau, I. Semeniouk, Y. Sirois, C. Thiebaux, J. Vanel, A. Zabi, J. Agram, A. Albert, L. Anckenmann, J. Andrea, F. Anstotz, A. Bergdolt, J. Berst, R. Blaes, D. Bloch, J. Brom, J. Cailleret, F. Charles, E. Christophel, G. Claus, J. Coffin, C. Colledani, J. Croix, E. Dangelser, N. Dick, F. Didierjean, F. Drouhin, W. Duliński, J. Ernenwein, R. Fang, J. Fontaine, G. Gaudiot, W. Geist, D. Gelé, T. Goeltzenlichter, U. Goerlach, P. Graehling, L. Gross, C. Hu, J. M. Helleboid, T. Henkes, M. Hoffer, C. Hoffmann, J. Hosselet, L. Houchu, Y. Hu, D. Huss, C. Illinger, F. Jeanneau, P. Juillot, T. Kachelhoffer, M. Kapp, H. Kettunen, L. Ayat, A. Bihan, A. Lounis, C. Maazouzi, V. Mack, P. Majewski, D. Mangeol, J. Michel, S. Moreau, C. Olivetto, A. Pallarès, Y. Patois, P. P. vorio, C. Racca, Y. Riahi, I. Ripp-Baudot, P. Schmitt, J. Schunck, G. Schuster, B. Schwaller, M. Sigward, J. Sohler, J. Speck, R. Strub, T. Todorov, R. Turchetta, P. Hove, D. Vintache, A. Zghiche, M. Ageron, J. Augustin, C. Baty, G. Baulieu, M. Bedjidian, J. Blaha, A. Bonnevaux, G. Boudoul, P. Brunet, E. Chabanat, E. Chabert, R. Chierici, V. Chorowicz, C. Combaret, D. Contardo, R. D. Negra, P. Depasse, O. Drapier, M. Dupanloup, T. Dupasquier, H. Mamouni, N. Estre, J. Fay, S. Gascon, N. Giraud, C. Girerd, G. Guillot, R. Haroutunian, B. Ille, M. Lethuillier, N. Lumb, C. Martin, H. Mathez, G. Maurelli, S. Muanza, P. Pangaud, S. Perriès, O. Ravat, E. Schibler, F. Schirra, G. Smadja, S. Tissot, B. Trocmé, S. Vanzetto, J. Walder, Y. Bagaturia, D. Mjavia, A. Mzhavia, Z. Tsamalaidze, V. Roǐnishvili, R. Adolphi, G. Anagnostou, R. Brauer, W. Braunschweig +499 moresemanticscholar +1 more sourceGeant4 developments and applications
IEEE Transactions on Nuclear Science, 2006 J. Allison, K. Amako, J. Apostolakis, H. Araújo, P. A. Dubois, M. Asai, G. Barrand, R. Capra, S. Chauvie, R. Chytracek, G. Cirrone, G. Cooperman, G. Cosmo, G. Cuttone, G. Daquino, M. Donszelmann, M. Dressel, G. Folger, F. Foppiano, J. Generowicz, V. Grichine, S. Guatelli, P. Gumplinger, A. Heikkinen, I. Hrivnácová, A. Howard, S. Incerti, V. Ivanchenko, T. Johnson, F. Jones, T. Koi, R. Kokoulin, M. Kossov, H. Kurashige, V. Lara, S. Larsson, F. Lei, O. Link, F. Longo, M. Maire, A. Mantero, B. Mascialino, I. Mclaren, P. M. Lorenzo, K. Minamimoto, K. Murakami, P. Nieminen, L. Pandola, S. Parlati, L. Peralta, J. Perl, A. Pfeiffer, M. Pia, A. Ribon, P. Rodrigues, G. Russo, S. Sadilov, G. Santin, T. Sasaki, D. Smith, N. Starkov, Satoshi Tanaka, E. Tcherniaev, B. Tomé, A. Trindade, P. Truscott, L. Urban, M. Verderi, A. Walkden, J. Wellisch, David Williams, D. Wright, H. Yoshida +72 moresemanticscholar +1 more source
