Results 181 to 190 of about 1,664,152 (285)

Temporal Susceptibility of Grapevine Pruning Wounds to Botryosphaeriaceae Host-Jumping Pathogens in Central Chile. [PDF]

J Fungi (Basel)
Hernández Y, Núñez FB, Quesada Y, Lolas M, Elfar K, Eskalen A, Gainza-Cortés F, Gundel PE, Sanfuentes E, Díaz GA.   +9 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Diagnostic reliability of O-RADS score based on non-dynamic contrast-enhanced MRI and apparent diffusion coefficient in characterization of adnexal masses. [PDF]

BMC Med Imaging
Elged BA, Abdelzaher DG, Elraouf GHA, Elmokadem AH, Hassan A, Saleh GA.   +5 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A procedure for rule extraction from a Self-Organising plasma disruption predictor for JET. [PDF]

Sci Rep
Setzu S, Aymerich E, Fanni A, Pisano F, Sias G, Cannas B, JET contributors, WPTE Team.   +7 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Predicting functional remission after antipsychotic discontinuation: a real-world study in schizophrenia. [PDF]

Psychol Med
Lu C, Dong Y, Zhai Z, Gao T, Luo M, Chang D, Chen J, Xue J, Zhao Y, Xiang Q, Li X, Ma X, Wei Z, Feng T, Liu D.   +14 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

An attention-demanding hunting paradigm engages the superior colliculus-zona incerta circuit mediating analgesia in male mice. [PDF]

Nat Commun
Zhang X, Liu XJ, Yin C, Zhou Q, Zhang J, Wang L, Cao JL, Xiao C, Zhou C.   +8 more
europepmc   +1 more source