Results 201 to 210 of about 2,152,852 (279)

DFT study on tunable electronic and adsorption properties of poly(vinyl alcohol)/copper oxide/graphene oxide hybrid nanostructures. [PDF]

Sci Rep
Ibrahim A, El Aal MA, El-Zahed H, Mabied AF.   +3 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Gut microbiome mediates an evolutionarily conserved social behavior in eusocial insects. [PDF]

Anim Microbiome
Magory Cohen T, Bodner L, Turjeman S, Sharon E, Cohen A, Bouchebti S, Tikhonov E, Koren O, Levin E.   +8 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Implementation of AESOP early-warning system for respiratory disease: a pilot and validation study using routinely collected data in Amazonas, Brazil. [PDF]

Lancet Reg Health Am
Marcilio I, Ramos PIP, Florentino PVT, Dos Santos ASM, de Araújo Oliveira V, Carreiro RP, Lima Danielli RC, Zany Dos Reis A, Ramos TCA, Bartholomay P, Coradi de Freitas DR, Martins Romano AP, Nunes Dos Santos C, Nienov OH, Gaete RAC, Oliveira JF, Cunha GG, Cunha MCSL, Brandão de Miranda R, Boaventura VS, Andrade RFS, Landau L, Penna GO, Barral-Netto M, ÆSOP Collaborating Team.   +24 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Novelty exploration-activated ensemble in the lateral hypothalamus confers analgesic and anxiolytic effects. [PDF]

Nat Commun
Jia T, Peng YT, Sun YL, Yin C, Gu X, Yang L, Zhang S, Cao JL, Xiao C, Zhou C.   +9 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Correction for Green et al., The intestinal microbiota impacts nutritional immunity and resistance to <i>Acinetobacter baumannii</i> pneumonia. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Cardiomyocyte-derived USP20 mitigates myocardial ischemia/reperfusion injury through deubiquitinating GRP78. [PDF]

Theranostics
Cheng Z, Zhong L, Ying M, Huang Z, Yang Z, Zhang W, Huang Z, Zhang N, Chen X, Fan X, Zhang Y, Zheng R, Ye K, Lin S, Huang W, Zhao G, Dai S.   +16 more
europepmc   +1 more source