Results 91 to 100 of about 8,918,962 (325)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

open access: yesFEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu   +17 more
wiley   +1 more source

Goodbye flat lymphoma biology

open access: yesFEBS Letters, EarlyView.
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria   +3 more
wiley   +1 more source

ARTICULAÇÕES ENTRE A ATUAÇÃO DO PROGRAMA BOLSA FAMÍLIA E O TRABALHO DE SEUS BENEFICIÁRIOS

open access: yesCaderno de Administração, 2020
Este estudo teve como objetivo analisar a articulação da atuação do Programa Bolsa Família (PBF) com aspectos relacionados ao trabalho. Para tal, realizou-se uma pesquisa in loco em Caruaru-PE.
Marllon Emanoel Souza Medeiros de Vasconcelos   +2 more
doaj  

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Point-of-interest recommendation based on non-adjacent trajectory interaction model [PDF]

open access: yesITM Web of Conferences
Next Point-of-Interest(POl)recommendation aims to predict users'future behaviors based on their historical trajectories, providing significant value toboth users and service providers.
Li Yang, Ma Ying, Liu Se
doaj   +1 more source

Face to Face, Carl Beam and Andy Warhol

open access: yes, 2018
Keira Koch ’19 examines representations of indigenous cultures in prints and photographs by American artist Andy Warhol and First Nations artist Carl Beam.
Koch, Keira B.
core  

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

open access: yesFEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson   +7 more
wiley   +1 more source

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

open access: yesFEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli   +10 more
wiley   +1 more source

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