Results 91 to 100 of about 4,136,812 (254)

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Toxicomania e posições subjetivas: uma dialética entre o prazer e o gozo

open access: yesPsicologia Revista, 2015
A literatura evidencia que o fenômeno da toxicomania não se deixa reduzir a qualquer classificação ou estrutura psicopatológica, pois oscila entre a neurose, a perversão e a psicose.
Ana Paula Paes de Paula
doaj  

Interview with Dr. Wesley Face

open access: yes, 1991
Tape recorded interviews conducted in 1991 by Dr. Robert Swanson with Dr. Wesley Face. Dr. Face earned his Bachelor of Science in industrial education and history in 1951 at Northern State Teacher's College in South Dakota.
Face, Dr. Wesley
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Forma, temporalità e immagini in alcuni Lieder 'acquatici' di Franz Schubert

open access: yes, 2022
Esame dei Lieder (testo poetico e composizione musicale) D 774, D 766, D 957/11 di Franz Schubert in prospettiva ...
G. La Face
core   +1 more source

ARTICULAÇÕES ENTRE A ATUAÇÃO DO PROGRAMA BOLSA FAMÍLIA E O TRABALHO DE SEUS BENEFICIÁRIOS

open access: yesCaderno de Administração, 2020
Este estudo teve como objetivo analisar a articulação da atuação do Programa Bolsa Família (PBF) com aspectos relacionados ao trabalho. Para tal, realizou-se uma pesquisa in loco em Caruaru-PE.
Marllon Emanoel Souza Medeiros de Vasconcelos   +2 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

A comprehensive review of Artificial Intelligence regulation: Weighing ethical principles and innovation

open access: yesJournal of Economy and Technology
We present a comprehensive review of Artificial Intelligence (AI) regulation, addressing the challenges and needs associated with governing rapidly evolving AI technologies.
Daniel Oliveira Cajueiro   +1 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Supply Chain Management in Services: an analysis of logistics operational activities of cinema chains in Belo Horizonte

open access: yesGEPROS: Gestão da Produção, Operações e Sistemas, 2014
Márcio Roberto Costa   +1 more
doaj   +1 more source

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