Results 121 to 130 of about 25,067,764 (296)

Bosphorus Database for 3D Face Analysis

open access: yes, 2008
A new 3D face database that includes a rich set of expressions, systematic variation of poses and different types of occlusions is presented in this paper. This database is unique from three aspects: i) the facial expressions are composed of judiciously selected subset of Action Units as well as the six basic emotions, and many actors/actresses are ...
Arman Savran   +6 more
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Interview with Lorna Wánosts’a7 Williams for Survival International

open access: yes, 2019
Material features an interview with Lorna Wánosts’a7 Williams for Survival International conducted by Gary Marcuse in Vancouver, B.C. Some questions are based on those provided by anthropologist Hugh Brody and Jo Woodman of Survival International for a ...
Face to Face Media
core   +1 more source

Analysis of Natural Characteristics of the Dual-Path Nutation Face Gear Transmission System

open access: yesApplied Sciences
The nutation face gear transmission combines the high contact ratio of face gears with the large reduction ratio of nutation drives, making it a promising transmission solution.
Yuxin Wang   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Interview with Lorna Wánosts’a7 Williams in Mount Currie

open access: yes, 1994
Production material centres around an interview conducted with Lorna Wánosts’a7 Williams at the home of Tsínay̓a7 (Georgina Nelson). In tape 1, Wánosts’a7 talks about meeting Lettie Battle and the parallels between Battle’s work with African American ...
Face to Face Media
core  

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