Results 81 to 90 of about 437,440 (245)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

Time-Efficient Hybrid Approach for Facial Expression Recognition [PDF]

, 2017
Facial expression recognition is an emerging research area for improving human and computer interaction. This research plays a significant role in the field of social communication, commercial enterprise, law enforcement, and other computer interactions.
Puthanidam, Roshni Velluva
core   +1 more source

Greedy Search for Descriptive Spatial Face Features

, 2017
Facial expression recognition methods use a combination of geometric and appearance-based features. Spatial features are derived from displacements of facial landmarks, and carry geometric information.
Benligiray, Burak, Gacav, Caner, Topal, Cihan   +2 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Characteristics of facial muscle activity during voluntary facial expressions: Imaging analysis of facial expressions based on myogenic potential data

Neuropsychopharmacology Reports, 2019
Purpose Facial expressions are formed by the coordination of facial muscles and reflect changes in emotion. Nurses observe facial expressions as way of understanding patients. This study conducted basic research using facial myogenic potential topography
Eriko Kuramoto, Saori Yoshinaga, Hiroyuki Nakao, Seiji Nemoto, Yasushi Ishida   +4 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Incorporating eyebrow and eye state information for facial expression recognition in mask-obscured scenes

Electronic Research Archive
Facial expression recognition plays a crucial role in human-computer intelligent interaction. Due to the problem of missing facial information caused by face masks, the average accuracy of facial expression recognition algorithms in mask-obscured scenes ...
Kun Zheng, Li Tian, Zichong Li, Hui Li, Junjie Zhang   +4 more
doaj   +1 more source

Dynamic Facial Expression of Emotion Made Easy [PDF]

, 2012
Facial emotion expression for virtual characters is used in a wide variety of areas. Often, the primary reason to use emotion expression is not to study emotion expression generation per se, but to use emotion expression in an application or research ...
Brinkman, Willem-Paul, Broekens, Joost, Qu, Chao   +2 more
core  

Enriched Long-term Recurrent Convolutional Network for Facial Micro-Expression Recognition

, 2018
Facial micro-expression (ME) recognition has posed a huge challenge to researchers for its subtlety in motion and limited databases. Recently, handcrafted techniques have achieved superior performance in micro-expression recognition but at the cost of ...
Khor, Huai-Qian, Lin, Weiyao, Phan, Raphael C. W., See, John   +3 more
core   +1 more source