Results 51 to 60 of about 47,625 (296)

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Evaluation of the Prevalence of Maxillary Sinuses Abnormalities through Spiral Computed Tomography (CT)

International Archives of Otorhinolaryngology, 2017
Introduction Maxillary sinus disease is common and numerous disorders can affect this anatomical area. Abnormalities can be classified as: non-neoplastic, neoplastic benign, and neoplastic malignant.
João Paulo Nunes Drumond, Bruna Bianca Allegro, Neil Ferreira Novo, Sérgio Luís de Miranda, Wilson Roberto Sendyk   +4 more
doaj   +1 more source

Malignant Facial Neoplasms Detected During the Comprehensive Optometry Exam

CRO (Clinical & Refractive Optometry) Journal, 2021
Skin carcinomas are the result of the malignant proliferation of epithelial keratinocytes. The two most common nonmelanoma skin cancers are basal cell carcinoma and squamous cell carcinoma and the latter has the potential to metastasize and cause morbidity and mortality.
Leslie R. Wilderson, Sujata Khosla
openaire   +1 more source

Epidemiologic profile of salivary gland neoplasms: analysis of 245 cases

, 2005
SummaryAim: The aim of the present study is to establish the relative frequency and distribution of benign and malignant epithelial neoplasms of salivary glands in the Pathology and Cytology Laboratory, Study design: Historic cohort. Material and method:
Soares, Andréa Ferreira, de Amorim, Rivadávio Fernandes Batista, de Almeida Freitas, Roseana, Lima, Solange Souza   +3 more
core   +1 more source

Cochlear erosion due to a facial nerve schwannoma [PDF]

, 2019
Facial nerve schwannomas are rare benign neoplasms. We report a case of a 60-year-old woman who initially presented with vestibular complaints. Magnetic resonance imaging (MRI) revealed a facial nerve schwannoma centered on the right geniculate ganglion ...
Bernaerts, Anja, Tony Puls, Puls, Tony, Zarowski, Andrzej, Somers, Thomas, van Dinther, Joost, Elke Loos, Vanspauwen, Robby, Anja Bernaerts, Casselman, Jan, Joost van Dinther, Wuyts, Laura, Jan W. Casselman, Bert De Foer, Andrzej Zarowski, Laura Wuyts, Erwin Offeciers, Thomas Somers, Offeciers, Erwin, De Loose, Elke, Robby Vanspauwen, Loos, Elke, De Foer, Bert, Casselman, Jan W.   +23 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Systematic review and meta-analysis of modified facelift incision versus modified Blair incision in parotidectomy

Scientific Reports, 2021
Surgical removal is the treatment of choice for many neoplasms of the parotid gland. This meta-analysis aimed to evaluate the differences between parotidectomy using a modified facelift incision (MFI) and parotidectomy using a modified Blair incision ...
Yi-Chan Lee, Wei-Chih Liao, Shih-Wei Yang, Cheng-Ming Luo, Yao-Te Tsai, Ming-Shao Tsai, Yi-Hsuan Lee, Li-Jen Hsin   +7 more
doaj   +1 more source

A Simplified approach for fabrication of custom tray for Facial prosthesis

, 2020
Maxillofacial defects are very common and can be due to congenital defect, trauma, infections and neoplasms of facial region. These defects can be restored using different materials and retention methods to give a life like appearance.
Sunit Kumar Jurel, Pooran Chand, Jyotsna Vimal, Raghuwar Dayal Singh*   +3 more
core   +1 more source