Results 51 to 60 of about 688,265 (303)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Effects of a facial nerve lesion on responses in forehead microvessels to conjunctival irritation and paced breathing [PDF]

, 2012
To investigate parasympathetic influences on the forehead microvasculature, blood flow was monitored bilaterally in seven participants with a unilateral facial nerve lesion during conjunctival irritation with Schirmer's strips and while breathing at 0.15.
Drummond, P.D.
core  

The Facial Nerve

, 2014
In case of an acute facial nerve palsy, thedifferential diagnosis is of utmost importance for addressing the correct therapeutical protocol as well as for foreseeing the possibility of its partial or total recovery.
Barbara Maurizio
core   +1 more source

Epineurial pseudocyst of the intratemporal facial nerve : a case series study [PDF]

, 2020
OBJECTIVES: The goal of this case series was to describe the clinical and radiological characteristics of epineurial pseudocysts of the intratemporal facial nerve (EPIFs) and to discuss the relevance in clinical practice.
Cammaert, Tom, Stefan Delrue, Heylbroeck, Philippe, Marc Lemmerling, Lemmerling, Marc, Tom Cammaert, Philippe Heylbroeck, Delrue, Stefan   +7 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Traumatic facial nerve injury: A case of facial nerve avulsion at the cerebellopontine angle

Radiology Case Reports, 2022
Post-traumatic facial nerve paralysis is a common disease, but intracranial facial nerve injury after blunt injury has rarely been reported. We report a case of facial nerve avulsion at the cerebellopontine angle.
Masumi Mizuki, MD, Fumio Suzuki, MD, PhD, Shiori Amemiya, MD, PhD, Hironobu Nishijima, MD, PhD, Yoshifumi Imai, MD, Osamu Abe, MD, PhD   +5 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Intratemporal Facial Nerve Schwannomas: A Review of 45 Cases in A Single Center

Diagnostics, 2022
There are no established indications for facial nerve schwannoma treatment, including surgery, radiation and follow-up observation, and it is difficult to determine treatment policy uniformly. The treatment policy was examined from each treatment course.
Tsubasa Kitama, Makoto Hosoya, Masaru Noguchi, Takanori Nishiyama, Takeshi Wakabayashi, Marie N. Shimanuki, Masaki Yazawa, Yasuhiro Inoue, Jin Kanzaki, Kaoru Ogawa, Naoki Oishi   +10 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source